(Q45318224)

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Pre-NOTCH Transcription and Translation

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1912408)

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8 July 2022

Pre-NOTCH Expression and Processing

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8 July 2022

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https://identifiers.org/reactome:R-HSA-1912408

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CCND1:CREBBP binds NOTCH1 promoter

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E2F1/3:DP1/2 binds NOTCH1 promoter

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NOTCH1 gene transcription

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NOTCH2 gene transcription

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NOTCH3 gene transcription

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NOTCH4 gene transcription

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TP53 binds promoters of MIR34 genes

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p53 positively regulates transcription of MIR34 microRNAs

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MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA

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MIR200B/C microRNAs bind NOTCH1 mRNA

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MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA

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MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA

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MIR150 microRNA binds 3'UTR of NOTCH3 mRNA

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MIR206 microRNA binds 3'UTR of NOTCH3 mRNA

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MIR181C microRNA binds 3'UTR of NOTCH4 mRNA

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MIR302A microRNA binds 3'UTR of NOTCH4 mRNA

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NOTCH1 mRNA translation controlled by miRNAs

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NOTCH2 mRNA translation controlled by miRNAs

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NOTCH3 mRNA translation controlled by miRNAs

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NOTCH4 mRNA translation controlled by miRNAs

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NOTCH1 coactivator complex binds NOTCH3 gene

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PRKCI phosphorylates ELF3

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ELF3 binds NOTCH3 gene promoter

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RUNX1 binds NOTCH4 gene

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NOTCH4 gene transcription is inhibited by RUNX1

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SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters

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SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters

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NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6

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Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

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A microRNA component of the p53 tumour suppressor network

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A homolog of Drosophila Notch expressed during mammalian development

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Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells

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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

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MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

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NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

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Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150.

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MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells.

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The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation

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Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

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Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

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8 July 2022

MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation

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Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

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Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment

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Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

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Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells

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MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

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Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis

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8 July 2022

Identifiers

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8 July 2022

(Q45318224)

Pre-NOTCH Transcription and Translation

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