(Q45318276)

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Degradation of GLI1 by the proteasome

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5610780)

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8 July 2022

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8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-5610780

1 reference

8 July 2022

PKA phosphorylates GLI1

1 reference

8 July 2022

SCF(beta-TrCP) ubiquitinates p-GLI1

1 reference

8 July 2022

GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

1 reference

8 July 2022

1 reference

8 July 2022

NUMB:ITCH bind and ubiquitnate GLI1

1 reference

8 July 2022

GLI1 is degraded by the proteasome after ubiquitination by ITCH

1 reference

8 July 2022

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

1 reference

8 July 2022

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

1 reference

8 July 2022

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

1 reference

8 July 2022

A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome

1 reference

8 July 2022

A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45318276)

Degradation of GLI1 by the proteasome

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