(Q50298947)

English

GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5610758)

In more languages

Statements

biological process

1 reference

8 July 2022

Degradation of GLI1 by the proteasome

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-5610758

1 reference

8 July 2022

ub-pS-GLI1:SUFU [ciliary base]

1

object has role

1 reference

8 July 2022

SUFU negative regulator of hedgehog signaling

1

object has role

1 reference

8 July 2022

26S proteasome [cytosol]

1

object has role

1 reference

8 July 2022

Dual degradation signals control Gli protein stability and tumor formation

1 reference

8 July 2022

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

1 reference

8 July 2022

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q50298947&oldid=2110803557"