(Q48364639)

11 February 2018

title

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. (English)

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11 February 2018

main subject

protein ubiquitination

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2

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11 February 2018

Enrico De Smaele

4

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11 February 2018

Agnese Po

5

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11 February 2018

Maurizio Alimandi

object named as

Maurizio Alimandi

7

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Giuseppe Giannini

object named as

Giuseppe Giannini

8

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author name string

Lucia Di Marcotullio

1

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11 February 2018

Azzura Greco

3

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11 February 2018

Maria Anna Sico

6

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11 February 2018

Marella Maroder

9

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11 February 2018

Isabella Screpanti

10

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11 February 2018

Alberto Gulino

11

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11 February 2018

publication date

19 November 2006

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11 February 2018

published in

Nature Cell Biology

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11 February 2018

volume

8

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11 February 2018

issue

12

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11 February 2018

page(s)

1415-1423

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11 February 2018

https://scigraph.springernature.com/pub.10.1038/ncb1510

exact match

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cites work

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

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7 January 2021

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

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7 January 2021

Murine numb regulates granule cell maturation in the cerebellum

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7 January 2021

Gli and hedgehog in cancer: tumours, embryos and stem cells.

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7 January 2021

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

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7 January 2021

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

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7 January 2021

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

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7 January 2021

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

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7 January 2021

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

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7 January 2021

In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

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7 January 2021

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

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7 January 2021

Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis

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7 January 2021

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

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7 January 2021

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

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7 January 2021

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage

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7 January 2021

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

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7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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7 January 2021

Dual degradation signals control Gli protein stability and tumor formation

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7 January 2021

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

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7 January 2021

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

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7 January 2021

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

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7 January 2021

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

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7 January 2021

Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors

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7 January 2021

The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system

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7 January 2021

Numb is an endocytic protein

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7 January 2021

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

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7 January 2021

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

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7 January 2021

Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster

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7 January 2021

The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

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7 January 2021

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

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7 January 2021

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

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7 January 2021

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

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7 January 2021

Absence of caspase 8 and high expression of PED protect primitive neural cells from cell death.

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7 January 2021

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

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7 January 2021

Identifiers

DOI

10.1038/NCB1510

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11 February 2018

PubMed ID

17115028

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11 February 2018