(Q34189079)

31 July 2017

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain (English)

1 reference

31 July 2017

protein ubiquitination

1 reference

Melanie A McGill

1

1 reference

PubMed ID

12682059

31 July 2017

C Jane McGlade

series ordinal

2

1 reference

PubMed ID

12682059

31 July 2017

language of work or name

English

0 references

publication date

7 April 2003

1 reference

Journal of Biological Chemistry

31 July 2017

1 reference

31 July 2017

278

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31 July 2017

23196-23203

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31 July 2017

25

1 reference

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

31 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Numb antagonizes Notch signaling to specify sibling neuron cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Asymmetric segregation of Numb and Prospero during cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Mouse numb is an essential gene involved in cortical neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Multiple roles of mouse Numb in tuning developmental cell fates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Notch signaling: cell fate control and signal integration in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Arbiter of differentiation and death: Notch signaling meets apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Involvement of Notch1 in the development of mouse mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Notch signalling pathway and human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Notch pathway: democracy and aristocracy in the selection of cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Nuclear access and action of notch in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Protein degradation: four E3s for the notch pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

RING finger proteins: mediators of ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Siah-1 binds and regulates the function of Numb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Calcium depletion dissociates and activates heterodimeric notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

Numb is an endocytic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302827200

21 January 2018

Identifiers

DOI

10.1074/JBC.M302827200

1 reference

31 July 2017

1 reference

PubMed ID

12682059