(Q45318300)

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Regulation of PTEN gene transcription

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8943724)

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8 July 2022

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https://identifiers.org/reactome:R-HSA-8943724

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TP53 binds the PTEN promoter

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EGR1 binds the PTEN gene promoter

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Activated PPARG binds PTEN gene promoter

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NR2E1 associated with transcription repressors binds PTEN promoter

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SALL4 binds the PTEN gene promoter

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SALL4 recruits NuRD to PTEN gene

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MECOM (EVI1) binds the PTEN gene promoter

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MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter

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SNAI1,SNAI2 bind the PTEN gene promoter

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JUN binds the PTEN gene promoter

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p-T69,T71-ATF2 binds PTEN gene promoter

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mTORC1 phosphorylates MAF1

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MAF1 translocates to the nucleus

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MAF1 binds the PTEN gene promoter

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PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN

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SALL4 is a key regulator of survival and apoptosis in human leukemic cells

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Regulation of PTEN transcription by p53

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Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis

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Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex

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MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription

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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

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Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

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SLUG is a direct transcriptional repressor of PTEN tumor suppressor

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Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1

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Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheli

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Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

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The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

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Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

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Identifiers

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8 July 2022

(Q45318300)

Regulation of PTEN gene transcription

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