(Q45345228)

13 December 2017

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. (English)

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13 December 2017

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Hata A

1

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13 December 2017

Lo RS

2

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13 December 2017

Wotton D

3

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13 December 2017

Lagna G

4

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13 December 2017

Massagué J

5

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13 December 2017

language of work or name

English

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publication date

1 July 1997

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13 December 2017

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13 December 2017

388

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13 December 2017

82-87

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13 December 2017

6637

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https://scigraph.springernature.com/pub.10.1038/40424

13 December 2017

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cites work

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

7 January 2021

A human Mad protein acting as a BMP-regulated transcriptional activator

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7 January 2021

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

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7 January 2021

TGF-beta signalling through the Smad pathway

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7 January 2021

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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7 January 2021

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7 January 2021

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

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7 January 2021

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

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7 January 2021

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

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7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

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7 January 2021

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

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7 January 2021

Mad-related genes in the human

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7 January 2021

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

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7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

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7 January 2021

Mechanism of activation of the TGF-beta receptor

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7 January 2021

Inhibition of activin receptor signaling promotes neuralization in Xenopus

1 reference

7 January 2021

Identifiers

DOI

10.1038/40424

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Dimensions Publication ID

13 December 2017

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