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Two isoforms of glutamate decarboxylase: why?
scientific article published in December 1998
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
review article
1 reference
stated in
Europe PubMed Central
title
Two isoforms of glutamate decarboxylase: why?
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
author
Jean-jacques Soghomonian
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
author name string
Martin DL
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
language of work or name
English
1 reference
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inferred from title
publication date
1 December 1998
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
published in
Trends in Pharmacological Sciences
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
volume
19
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
page(s)
500-505
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
issue
12
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
cites work
Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse
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7 January 2021
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Characterization of a cDNA coding for rat glutamic acid decarboxylase
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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Two genes encode distinct glutamate decarboxylases
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Rat brain glutamic acid decarboxylase sequence deduced from a cloned cDNA.
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Mapping of glutamic acid decarboxylase (GAD) genes
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Structure and the promoter region of the mouse gene encoding the 67-kD form of glutamic acid decarboxylase
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reference URL
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7 January 2021
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Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms
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reference URL
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7 January 2021
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Different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles.
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region
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7 January 2021
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Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase
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7 January 2021
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A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Regulation of gamma-aminobutyric acid synthesis in the brain
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Cofactor interactions and the regulation of glutamate decarboxylase activity.
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Multiple elements regulate GAD65 transcription.
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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inferred from DOI database lookup
Structure and alternative promoters of the mouse glutamic acid decarboxylase 67 gene
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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Effects of increased gamma-aminobutyric acid levels on GAD67 protein and mRNA levels in rat cerebral cortex.
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels.
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures
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Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA).
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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Rat-1 fibroblasts engineered with GAD65 and GAD67 cDNAs in retroviral vectors produce and release GABA.
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Two distinct mechanisms, differentially affected by excitatory amino acids, trigger GABA release from fetal mouse striatal neurons in primary culture
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7 January 2021
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Nonvesicular release of neurotransmitter.
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Glutamate decarboxylase immunoreactivity and gamma-[3H] aminobutyric acid accumulation within the same neurons in dissociated cell cultures of cerebral cortex
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Depolarization without calcium can release gamma-aminobutyric acid from a retinal neuron
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Horizontal cells in cat and monkey retina express different isoforms of glutamic acid decarboxylase
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Co-release of acetylcholine and gamma-aminobutyric acid by a retinal neuron
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Displaced starburst amacrine cells of the rabbit retina contain the 67-kDa isoform, but not the 65-kDa isoform, of glutamate decarboxylase
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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The parafascicular thalamic nucleus modulates messenger RNA encoding glutamate decarboxylase 67 in rat striatum.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Dopaminergic and glutamatergic blocking drugs differentially regulate glutamic acid decarboxylase mRNA in mouse brain
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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MK-801 decreases striatal and cortical GAD65 mRNA levels
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Stimulation of GABA release from retinal horizontal cells by potassium and acidic amino acid agonists
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Rapid increases in cerebellar Purkinje cell glutamic acid decarboxylase (GAD67) mRNA after lesion-induced increases in cell firing.
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Expression of glutamic acid decarboxylase mRNA in normal and monocularly deprived cat visual cortex
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Changes in glutamic acid decarboxylase mRNA in the pallidum of the rat following unilateral damage of the striatum and overlying cortex
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Increased glutamate decarboxylase mRNA levels in the striatum and pallidum of MPTP-treated primates.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Glutamate decarboxylase (GAD65) mRNA levels in the striatum and pallidum of MPTP-treated monkeys
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Spontaneous firing patterns of identified spiny neurons in the rat neostriatum
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7 January 2021
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Comparative distribution of messenger RNAs encoding glutamic acid decarboxylases (Mr 65,000 and Mr 67,000) in the basal ganglia of the rat.
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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The origins of two-state spontaneous membrane potential fluctuations of neostriatal spiny neurons.
1 reference
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7 January 2021
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Bursting and tonic discharges in two classes of reticular thalamic neurons
1 reference
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reference URL
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7 January 2021
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Functional dynamics of GABAergic inhibition in the thalamus.
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamate decarboxylase (GAD67 and GAD65) gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian monkeys.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamate decarboxylase messenger RNA in rat pallidum: comparison of the effects of haloperidol, clozapine and combined haloperidol-scopolamine treatments
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Differential regulation of mRNA levels encoding for the two isoforms of glutamate decarboxylase (GAD65 and GAD67) by dopamine receptors in the rat striatum
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Acute versus chronic haloperidol: relationship between tolerance to catalepsy and striatal and accumbens dopamine, GABA and acetylcholine release.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regional specific effects of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Influence of dopamine on GABA release in striatum: evidence for D1-D2 interactions and non-synaptic influences
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Glutamate decarboxylase (GAD65) gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Region-specific regulation of glutamic acid decarboxylase (GAD) mRNA expression in central stress circuits.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Increased GABAergic transmission in medial hypothalamus facilitates lordosis but has the opposite effect in preoptic area.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Estrogen modulation of mRNA levels for the two forms of glutamic acid decarboxylase (GAD) in female rat brain
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
GABAergic neuronal activity and mRNA levels for both forms of glutamic acid decarboxylase (GAD65 and GAD67) are reduced in the diagonal band of Broca during the afternoon of proestrus.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Intracerebral administration of antisense oligodeoxynucleotides to GAD65 and GAD67 mRNAs modulate reproductive behavior in the female rat.
1 reference
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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
based on heuristic
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Heteromers of glutamate decarboxylase isoforms occur in rat cerebellum
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901270-X
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7 January 2021
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Identifiers
DOI
10.1016/S0165-6147(98)01270-X
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
PubMed ID
9871412
1 reference
stated in
Europe PubMed Central
PubMed ID
9871412
retrieved
13 December 2017
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