(Q45419109)

14 December 2017

Pathogenesis of HIV infection: what the virus spares is as important as what it destroys (English)

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14 December 2017

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Zvi Grossman

1

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14 December 2017

Martin Meier-Schellersheim

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2

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14 December 2017

William E Paul

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3

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14 December 2017

Louis J Picker

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4

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14 December 2017

language of work or name

English

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publication date

1 March 2006

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14 December 2017

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14 December 2017

12

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14 December 2017

289-295

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14 December 2017

3

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https://scigraph.springernature.com/pub.10.1038/nm1380

14 December 2017

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cites work

Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract

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CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

21 January 2018

1 reference

Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy

21 January 2018

1 reference

Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells.

21 January 2018

1 reference

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

21 January 2018

1 reference

Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection

21 January 2018

1 reference

Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivo

21 January 2018

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Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection.

21 January 2018

1 reference

HIV pathogenesis: the first cut is the deepest.

21 January 2018

1 reference

CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function

21 January 2018

1 reference

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

21 January 2018

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Lymphocyte homing to the gut: attraction, adhesion, and commitment

21 January 2018

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Organizing a mucosal defense

21 January 2018

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CCR7 expression and memory T cell diversity in humans

21 January 2018

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Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

21 January 2018

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Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

21 January 2018

1 reference

Distinct lineages of T(H)1 cells have differential capacities for memory cell generation in vivo.

21 January 2018

1 reference

Lineage relationship and protective immunity of memory CD8 T cell subsets

21 January 2018

1 reference

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

21 January 2018

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Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells

21 January 2018

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Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes

21 January 2018

1 reference

Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection

21 January 2018

1 reference

The anatomical basis of intestinal immunity

21 January 2018

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The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions

21 January 2018

1 reference

Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection

21 January 2018

1 reference

Turnover rates of B cells, T cells, and NK cells in simian immunodeficiency virus-infected and uninfected rhesus macaques

21 January 2018

1 reference

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways

21 January 2018

1 reference

HIV preferentially infects HIV-specific CD4+ T cells

21 January 2018

1 reference

CD8+ T cells specific for EBV, cytomegalovirus, and influenza virus are activated during primary HIV infection.

21 January 2018

1 reference

Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire.

21 January 2018

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Peripheral T cell survival

21 January 2018

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Population biology of lymphocytes: the flight for survival

21 January 2018

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Homeostasis of alpha beta TCR+ T cells.

21 January 2018

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Rapid turnover of T lymphocytes in SIV-infected rhesus macaques.

21 January 2018

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Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection

21 January 2018

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Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients

21 January 2018

1 reference

T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock

21 January 2018

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Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV

21 January 2018

1 reference

Turnover of lymphocytes and conceptual paradigms in HIV infection

21 January 2018

1 reference

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

21 January 2018

1 reference

Viral dynamics in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy

21 January 2018

1 reference

Interactions between commensal intestinal bacteria and the immune system

21 January 2018

1 reference

In vivo activation of antigen-specific CD4 T cells.

21 January 2018

1 reference

HIV disease: fallout from a mucosal catastrophe?

21 January 2018

1 reference

Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.

21 January 2018

1 reference

HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

21 January 2018

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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

21 January 2018

1 reference

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

21 January 2018

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Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection

21 January 2018

1 reference

Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.

21 January 2018

1 reference

Recruitment of HIV and its receptors to dendritic cell-T cell junctions.

21 January 2018

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HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse

21 January 2018

1 reference

Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers

21 January 2018

1 reference

Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication

21 January 2018

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Viral dynamics of acute HIV-1 infection

21 January 2018

1 reference

Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.

21 January 2018

1 reference

Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA.

21 January 2018

1 reference

Factors influencing T-cell turnover in HIV-1-seropositive patients

21 January 2018

1 reference

Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

21 January 2018

1 reference

Measurement and modeling of human T cell kinetics.

21 January 2018

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Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection

21 January 2018

1 reference

Concomitant regulation of T-cell activation and homeostasis

21 January 2018

1 reference

Restoration of the immune system with anti-retroviral therapy

21 January 2018

1 reference

From HIV infection to AIDS: are the manifestations of effective immune resistance misinterpreted?

21 January 2018

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CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency.

21 January 2018

1 reference

Direct HIV cytopathicity cannot account for CD4 decline in AIDS in the presence of homeostasis: a worst-case dynamic analysis

21 January 2018

1 reference

Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

21 January 2018

1 reference

CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy

21 January 2018

1 reference

CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.

21 January 2018

1 reference

The dynamics of CD4+ T-cell depletion in HIV disease

21 January 2018

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HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation.

21 January 2018

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Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

21 January 2018

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High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

21 January 2018

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Dynamics of fine T-cell subsets during HIV disease and after thymic ablation by mediastinal irradiation

21 January 2018

1 reference

The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection

21 January 2018

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Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease

21 January 2018

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Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS.

21 January 2018

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Development and homeostasis of T cell memory in rhesus macaque

21 January 2018

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Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines

21 January 2018

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7 January 2021

T cell dynamics in HIV-1 infection

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7 January 2021

Alveolar macrophage activation in HIV infection

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7 January 2021

The dominant source of CD4+ and CD8+ T-cell activation in HIV infection is antigenic stimulation

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7 January 2021

T-cell homeostasis in HIV infection is neither failing nor blind: modified cell counts reflect an adaptive response of the host

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7 January 2021

CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

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7 January 2021

HIV tropism and CD4+ T-cell depletion

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7 January 2021

Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor.

1 reference

7 January 2021

HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes

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7 January 2021

Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination

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7 January 2021

HIV-specific effector cytotoxic T lymphocytes and HIV-producing cells colocalize in white pulps and germinal centers from infected patients

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7 January 2021

Immune activation in the context of HIV infection

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7 January 2021

AIDS vaccine models: challenging challenge viruses

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7 January 2021

Prospects for an AIDS vaccine

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7 January 2021

Identifiers

DOI

10.1038/NM1380

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Dimensions Publication ID

14 December 2017

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