(Q45440609)

14 December 2017

Emerging therapies for hepatitis C virus infection (English)

1 reference

14 December 2017

1 reference

Dymock BW

1

1 reference

PubMed ID

15989494

14 December 2017

language of work or name

English

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publication date

1 April 2001

1 reference

Expert Opinion on Emerging Drugs

14 December 2017

1 reference

14 December 2017

6

1 reference

14 December 2017

1

1 reference

14 December 2017

13-42

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The scientific challenge of hepatitis C.

14 December 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

The prevalence of hepatitis C virus infection in the United States, 1988 through 1994

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Replication of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Risk factors for the rising rates of primary liver cancer in the United States.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C virus: current understanding and prospects for future therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

The treatment of chronic viral hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Peginterferon alfa-2a in patients with chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Cell-based and animal models for hepatitis B and C viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C virus viremia in SCID-->BNX mouse chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Homotypic interaction and multimerization of hepatitis C virus core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Complex processing and protein:protein interactions in the E2:NS2 region of HCV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

A second hepatitis C virus-encoded proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Mechanism of autoproteolysis at the NS2-NS3 junction of the hepatitis C virus polyprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

The design and synthesis of potent inhibitors of hepatitis C virus NS3-4A proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Peptide-based inhibitors of the hepatitis C virus serine protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Inhibitory effects of podophyllotoxin derivatives on herpes simplex virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Establishment of an in vitro assay system for screening hepatitis C virus protease inhibitors using high performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Novel hepatitis C virus protease inhibitors: thiazolidine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Non-peptide inhibitors of HCV serine proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

An enzyme-linked immunosorbent assay for detecting proteolytic activity of hepatitis C virus proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Design of selective eglin inhibitors of HCV NS3 proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Isolation and characterization of monoclonal antibodies that inhibit hepatitis C virus NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Selection of RNA aptamers that bind specifically to the NS3 protease of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Solution structure of substrate-based ligands when bound to hepatitis C virus NS3 protease domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Functional interactions between conserved motifs of the hepatitis C virus RNA helicase protein NS3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

DNA helicase activity of the hepatitis C virus nonstructural protein 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

A novel recombinant single-chain hepatitis C virus ns3-ns4a protein with improved helicase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Subcellular localisation of NS3 in HCV-infected hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Integrity of the NS5A (amino acid 2209 to 2248) region in hepatitis C virus 1b patients non-responsive to interferon therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Mutations in NS5A region of hepatitis C virus genome correlate with presence of NS5A antibodies and response to interferon therapy for most common European hepatitis C virus genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Expression of hepatitis C virus NS5B protein: characterization of its RNA polymerase activity and RNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Selective stimulation of hepatitis C virus and pestivirus NS5B RNA polymerase activity by GTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Expression, purification, and partial characterization of HCV RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Structure of the RNA-dependent RNA polymerase of poliovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Antisense oligonucleotides as therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Phosphorothioate oligodeoxynucleotides—anti-sense inhibitors of gene expression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Core specific antisense phosphorothioate oligodeoxynucleotides as potent and specific inhibitors of hepatitis C viral translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Comparative inhibitory potential of differently modified antisense oligodeoxynucleotides on hepatitis C virus translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV poliovirus using synthetic stabilized ribozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Inhibition of hepatitis C virus-directed gene expression by a DNA ribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Ribavirin for respiratory syncytial virus lower respiratory tract infection. A systematic overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Combination treatment for chronic hepatitis C: what is the role of ribavirin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Use of the yellow fever virus vaccine strain 17D for the study of strategies for the treatment of yellow fever virus infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Mode of action of ribavirin: effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

IMP dehydrogenase, an enzyme linked with proliferation and malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Metabolism of 5-amino-1-β-d-ribofuranosyl- imidazole-4-carboxamide and related five-membered heterocycles to 5′-triphosphates in human blood and L5178Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Binding of hepatitis C virus to CD81

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Hepatitis C virus envelope protein E2 binds to CD81 of tamarins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Crystallization and preliminary crystallographic studies on the large extracellular domain of human CD81, a tetraspanin receptor for hepatitis C virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

In vitro infection of adult normal human hepatocytes in primary culture by hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

Similarities in RNA helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728214.6.1.13

21 January 2018

Identifiers

DOI

10.1517/14728214.6.1.13

1 reference

14 December 2017

1 reference

PubMed ID

15989494