(Q45750469)

English

Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication

scientific article published in April 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

Hepatitis C virus

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Darius Moradpour

5

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

author name string

Polyak SJ

1

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

Paschal DM

2

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

McArdle S

3

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

Gale MJ Jr

4

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

Gretch DR

6

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

language of work or name

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publication date

1 April 1999

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

29

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

4

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

1262-1271

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

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National Institutes of Health Consensus Development Conference Panel statement: management of hepatitis C

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Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial

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Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial

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Therapy of hepatitis C: overview

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Therapy of hepatitis C: meta-analysis of interferon alfa-2b trials

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Predicting interferon therapy efficacy from hepatitis C virus genotype and RNA titer

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Factors useful in predicting the response to interferon therapy in chronic hepatitis C.

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Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus

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Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C.

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Prediction of response to interferon treatment of chronic hepatitis C.

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Genotypic analysis of hepatitis C virus in American patients

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Antiviral effect of lymphoblastoid interferon-alpha on hepatitis C virus in patients with chronic hepatitis type C.

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Serum hepatitis C virus RNA level as a predictor of subsequent response to interferon-alpha therapy in Japanese patients with chronic hepatitis C.

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Serum hepatitis C virus RNA levels in chronic hepatitis C--importance for outcome of interferon alfa-2b treatment

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Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

1 reference

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Hypervariable regions in the putative glycoprotein of hepatitis C virus

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Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization

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Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

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Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus

1 reference

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Virus isolate-specific antibodies against hypervariable region 1 of the hepatitis C virus second envelope protein, gp70.

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Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients

1 reference

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Hepatitis C viral complexity detected by single-strand conformation polymorphism and response to interferon therapy

1 reference

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7 January 2021

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The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients

1 reference

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Assessment of hepatitis C virus quasispecies heterogeneity by gel shift analysis: correlation with response to interferon therapy

1 reference

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Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment

1 reference

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based on heuristic

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Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

1 reference

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7 January 2021

based on heuristic

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Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

1 reference

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7 January 2021

based on heuristic

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Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection

1 reference

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based on heuristic

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Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy

1 reference

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The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus

1 reference

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Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients

1 reference

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based on heuristic

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Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.

1 reference

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Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa

1 reference

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based on heuristic

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Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity.

1 reference

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Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations

1 reference

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Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b.

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Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.

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Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit

1 reference

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Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

1 reference

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Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

1 reference

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Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis

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1 reference

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The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase

1 reference

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The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity

1 reference

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1 reference

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Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing

1 reference

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based on heuristic

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The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor

1 reference

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The amino terminal deletion mutants of hepatitis C virus nonstructural protein NS5A function as transcriptional activators in yeast

1 reference

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based on heuristic

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Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

1 reference

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A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

1 reference

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

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Identifiers

10.1002/HEP.510290438

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

http://europepmc.org/abstract/MED/10094974

ResearchGate publication ID

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