(Q45757602)

15 December 2017

title

Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants (English)

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15 December 2017

author name string

Pelosi E

series ordinal

1

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15 December 2017

Mulamba GB

series ordinal

2

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15 December 2017

Coen DM

series ordinal

3

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15 December 2017

publication date

1 January 1998

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15 December 2017

published in

Antiviral Research

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15 December 2017

volume

37

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15 December 2017

issue

1

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15 December 2017

page(s)

17-28

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15 December 2017

Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors

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Acyclovir-resistant, pathogenic herpesviruses

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Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1

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Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine

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Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

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A genetic approach to promoter recognition during trans induction of viral gene expression

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Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir

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7 January 2021

Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model

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Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

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Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir

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7 January 2021

Cooperative effects between two acyclovir resistance loci in herpes simplex virus

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Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

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Evidence that the gene for herpes simplex virus type 1 DNA polymerase accounts for the capacity of an intertypic recombinant to spread from eye to central nervous system

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Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

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Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition

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Utilization of internal AUG codons for initiation of protein synthesis directed by mRNAs from normal and mutant genes encoding herpes simplex virus-specified thymidine kinase

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Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability

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7 January 2021

Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase

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7 January 2021

Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice

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7 January 2021

Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient.

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7 January 2021

Virus drug-resistance: mechanisms and consequences

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7 January 2021

Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities

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7 January 2021

Nucleotide sequences responsible for the inability of a herpes simplex virus type 2 strain to grow in human lymphocytes are identical to those responsible for its inability to grow in mouse tissues following ocular infection

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7 January 2021

The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency

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7 January 2021

Mode of action of (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine against herpesviruses

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7 January 2021

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

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7 January 2021

Correlation between response to acyclovir and foscarnet therapy and in vitro susceptibility result for isolates of herpes simplex virus from human immunodeficiency virus-infected patients

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7 January 2021

Foscarnet-resistant herpes simplex virus infection in patients with AIDS.

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7 January 2021

Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir

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7 January 2021

Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes

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7 January 2021

Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2.

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7 January 2021

Intracerebral Inoculation of Newborn and Adult Mice with Thymidine Kinase-Deficient Mutants of Herpes Simplex Virus Type 1

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7 January 2021

Genetic analysis of temperature-sensitive mutants of HSV-1: The combined use of complementation and physical mapping for cistron assignment

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7 January 2021

10.1016/S0166-3542(97)00054-5

Identifiers

DOI

1 reference

15 December 2017

1 reference

15 December 2017