(Q45856156)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

review article

1 reference

title

Gene therapy for inherited neurological disorders: towards therapeutic intervention in the Lesch-Nyhan syndrome (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

0 references

0 references

5

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9 December 2019

author name string

P R Lowenstein

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

T D Southgate

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

J R Smith-Arica

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

J Smith

4

1 reference

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9 December 2019

publication date

1 January 1998

1 reference

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Progress in Brain Research

9 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

volume

117

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

page(s)

485-501

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Recombinant human adenovirus with rat MIP-2 gene insertion causes prolonged PMN recruitment to the murine brain.

9 December 2019

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Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.

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7 January 2021

The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response

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7 January 2021

A dopamine deficiency model of Lesch-Nyhan disease--the neonatal-6-OHDA-lesioned rat.

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7 January 2021

Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (HSV1) vector, but not recombinant adenovirus vectors

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7 January 2021

Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination

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7 January 2021

Adenovirus gene transfer causes inflammation in the brain

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7 January 2021

Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion

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The role of CTLA-4 in the regulation and initiation of T-cell responses

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7 January 2021

Dopaminergic neurons protected from degeneration by GDNF gene therapy

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7 January 2021

Construction of Biologically Functional Bacterial Plasmids In Vitro

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7 January 2021

Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer

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7 January 2021

Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts

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7 January 2021

Genes, disease and medicine

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7 January 2021

Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors

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7 January 2021

Intercellular trafficking and protein delivery by a herpesvirus structural protein

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7 January 2021

HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome

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7 January 2021

Presynaptic dopaminergic deficits in Lesch-Nyhan disease

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7 January 2021

Prospects for gene therapy in Parkinson's disease

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7 January 2021

Use of tetracycline-controlled gene expression systems to study mammalian cell cycle.

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7 January 2021

Gene therapy for human genetic disease?

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7 January 2021

Persistent transgene expression in the hypothalamus following stereotaxic delivery of a recombinant adenovirus: suppression of the immune response with cyclosporin

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7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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7 January 2021

Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig

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7 January 2021

Adenoviral vector-mediated gene expression in the nervous system of immunocompetent Wistar and T cell-deficient nude rats: preferential survival of transduced astroglial cells in nude rats.

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7 January 2021

Transient immunosuppression with FK506 permits long-term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat.

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7 January 2021

Neural transplantation studies reveal the brain's capacity for continuous reconstruction.

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7 January 2021

Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli

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7 January 2021

Animal models of Lesch-Nyhan syndrome

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7 January 2021

Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization

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7 January 2021

Brain purines in a genetic mouse model of Lesch-Nyhan disease

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7 January 2021

Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease

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7 January 2021

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

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7 January 2021

Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung.

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7 January 2021

Functional and molecular differentiation of the dopamine system induced by neonatal denervation

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7 January 2021

Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver

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7 January 2021

Biological therapies for Alzheimer's disease: focus on trophic factors

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7 January 2021

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

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7 January 2021

Regulation of T and B cell responses by modulating interactions between CD28/CTLA4 and their ligands, CD80 and CD86.

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7 January 2021

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

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7 January 2021

CD28/B7 system of T cell costimulation

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7 January 2021

A FAMILIAL DISORDER OF URIC ACID METABOLISM AND CENTRAL NERVOUS SYSTEM FUNCTION

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7 January 2021

Biochemical Evidence of Dysfunction of Brain Neurotransmitters in the Lesch-Nyhan Syndrome

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7 January 2021

Why are we doing so much cancer gene therapy? Disentangling the scientific basis from the origins of gene therapy

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7 January 2021

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7 January 2021

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

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7 January 2021

Lesch-Nyhan syndrome and its pathogenesis: normal nicotinamide-adenine dinucleotide but reduced ATP concentrations that correlate with reduced poly(ADP-ribose) synthetase activity in HPRT-deficient lymphoblasts

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7 January 2021

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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7 January 2021

Bacterial virus gene expression in human cells

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7 January 2021

Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro

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7 January 2021

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT

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7 January 2021

Introduction of the glutamate receptor subunit 1 into motor neurons in vitro and in vivo using a recombinant herpes simplex virus

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7 January 2021

Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector

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7 January 2021

Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells

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7 January 2021

Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer

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7 January 2021

Getting hydrophilic compounds into cells: lessons from homeopeptides

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7 January 2021

The integrated state of viral DNA in SV40-transformed cells

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7 January 2021

Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression

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7 January 2021

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

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7 January 2021

Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors

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7 January 2021

Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus

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7 January 2021

Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition

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7 January 2021

Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex

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7 January 2021

Hormone replacement: therapeutic strategies in the treatment of Alzheimer’s disease and ageing-related cognitive disorders

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7 January 2021

Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors.

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7 January 2021

Adaptation of a Retrovirus as a Eucaryotic Vector Transmitting the Herpes Simplex Virus Thymidine Kinase Gene

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7 January 2021

Molecular biology, nucleic acids, and the future of medicine

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7 January 2021

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

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7 January 2021

Evidence that the adenoviral vector containing the CTLA4-Ig gene improves transgene expression and graft survival

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7 January 2021

An early history of gene transfer and therapy

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7 January 2021

Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo

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7 January 2021

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

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7 January 2021

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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7 January 2021

Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice

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7 January 2021

Gene transfer by adeno-associated virus vectors into the central nervous system

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7 January 2021

Gene therapy for central nervous system injury: the use of cationic liposomes: an invited review

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7 January 2021

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

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7 January 2021

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

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7 January 2021

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

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7 January 2021

Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome

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7 January 2021

10.1016/S0079-6123(08)64034-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9932427%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

1 reference