(Q45859665)

17 December 2017

title

Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial (English)

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17 December 2017

main subject

phase I clinical trial

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metastatic breast cancer

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Stewart AK

1

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17 December 2017

Lassam NJ

2

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17 December 2017

Quirt IC

3

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17 December 2017

Bailey DJ

4

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17 December 2017

Rotstein LE

5

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17 December 2017

Krajden M

6

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17 December 2017

Dessureault S

7

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17 December 2017

Gallinger S

8

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17 December 2017

Cappe D

9

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17 December 2017

Wan Y

10

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17 December 2017

Addison CL

11

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17 December 2017

Moen RC

12

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17 December 2017

Gauldie J

13

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17 December 2017

Graham FL

14

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17 December 2017

publication date

1 March 1999

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

6

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17 December 2017

page(s)

350-363

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17 December 2017

issue

3

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.gt.3300833

exact match

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cites work

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Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene

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Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

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Retroviral vector-mediated cytokine-gene transfer into tumor cells

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Antitumor response independent of functional B or T lymphocytes induced by the local and sustained release of interleukin-2 by the tumor cells

21 January 2018

1 reference

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Induction of antitumor immunity by interleukin-2 gene-transduced mouse mammary tumor cells versus transduced mammary stromal fibroblasts

21 January 2018

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Immune reactions induced by interleukin-2 transfected colorectal cancer cells in vitro: predominant induction of lymphokine-activated killer cells

21 January 2018

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Adenoviral interleukin-2 gene transfer into P815 tumor cells abrogates tumorigenicity and induces antitumoral immunity in mice

21 January 2018

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Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model

21 January 2018

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Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors

21 January 2018

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Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA.

21 January 2018

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Adenovirus infection in cystic fibrosis patients: implications for the use of adenoviral vectors for gene transfer

21 January 2018

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Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis

21 January 2018

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Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination

21 January 2018

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Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients

21 January 2018

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Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNF alpha

21 January 2018

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Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

21 January 2018

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Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression

21 January 2018

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Human gene marker/therapy clinical protocols

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3300833

7 January 2021

A phase I study of adenovirus mediated gene transfer of interleukin 2 cDNA into metastatic breast cancer or melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3300833

7 January 2021

Immune response to recombinant capsid proteins of adenovirus in humans: antifiber and anti-penton base antibodies have a synergistic effect on neutralizing activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3300833

7 January 2021

Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3300833

7 January 2021

Induction of tumor-specific cytotoxic T lymphocytes and natural killer cells by tumor cells transfected with the interleukin-2 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3300833

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3300833

1 reference

17 December 2017

Dimensions Publication ID

0 references

1 reference

17 December 2017