(Q45864168)

17 December 2017

title

CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack (English)

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17 December 2017

author name string

M Chmielewski

series ordinal

1

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17 December 2017

A A Hombach

series ordinal

2

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17 December 2017

H Abken

series ordinal

3

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17 December 2017

publication date

14 October 2010

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

18

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17 December 2017

issue

1

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17 December 2017

page(s)

62-72

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/gt.2010.127

exact match

0 references

cites work

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Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes

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Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy

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Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule

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Coupling CD28 co-stimulation to immunoglobulin T-cell receptor molecules: the dynamics of T-cell proliferation and death

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CD28 costimulation overcomes transforming growth factor-beta-mediated repression of proliferation of redirected human CD4+ and CD8+ T cells in an antitumor cell attack

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Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

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A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

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Cancer regression in patients after transfer of genetically engineered lymphocytes

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Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity

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The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

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Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

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Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

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On the dynamics of TCR:CD3 complex cell surface expression and downmodulation

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Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation

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7 January 2021

Signals and sequences that control CD28 localization to the central region of the immunological synapse

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7 January 2021

T cell activation by antibody-like immunoreceptors: increase in affinity of the single-chain fragment domain above threshold does not increase T cell activation against antigen-positive target cells but decreases selectivity.

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CD28 and CTLA-4 coreceptor expression and signal transduction

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Cutting edge: distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells

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Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors

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T cell retargeting with MHC class I-restricted antibodies: the CD28 costimulatory domain enhances antigen-specific cytotoxicity and cytokine production

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T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells

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A receptor/cytoskeletal movement triggered by costimulation during T cell activation

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T lymphocyte costimulation mediated by reorganization of membrane microdomains

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The immunological synapse and CD28-CD80 interactions.

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Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

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7 January 2021

T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

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7 January 2021

Novel mechanism of signaling by CD28.

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A retroviral vector system 'STITCH' in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes

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Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

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Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions in the center of the antibody binding site

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Improved short- and long-term XTT-based colorimetric cellular cytotoxicity assay for melanoma and other tumor cells

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7 January 2021

Identifiers

DOI

10.1038/GT.2010.127

1 reference

17 December 2017

Dimensions Publication ID

1039814805

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1 reference

17 December 2017