(Q45868519)

17 December 2017

title

Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium (English)

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17 December 2017

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7

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17 December 2017

author name string

T D Southgate

1

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17 December 2017

D Bain

2

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17 December 2017

L D Fairbanks

3

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17 December 2017

A E Morelli

4

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17 December 2017

A T Larregina

5

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17 December 2017

H A Simmonds

6

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17 December 2017

P R Löwenstein

8

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17 December 2017

publication date

1 December 1999

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17 December 2017

published in

Metabolic Brain Disease

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17 December 2017

volume

14

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17 December 2017

issue

4

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17 December 2017

page(s)

205-221

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17 December 2017

HPRT-APRT-deficient mice are not a model for lesch-nyhan syndrome

cites work

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12 December 2020

Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice

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12 December 2020

Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis

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12 December 2020

Altered erythrocyte nucleotide patterns are characteristic of inherited disorders of purine or pyrimidine metabolism

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12 December 2020

Craniocerebral magnetic resonance imaging measurement and findings in Lesch-Nyhan syndrome

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12 December 2020

Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization

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12 December 2020

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT

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12 December 2020

Regulation of purine uptake in normal and neoplastic cells

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12 December 2020

Gene therapy for human genetic disease?

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12 December 2020

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

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12 December 2020

Kinetic studies of hypoxanthine-guanine phosphoribosyltransferase in intact cells

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12 December 2020

Simultaneous estimation of rates of pyrimidine and purine nucleotide synthesis de novo in cultured human cells

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12 December 2020

Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity

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12 December 2020

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

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12 December 2020

Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector

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12 December 2020

Utilization of Purines by an HPRT Variant in an Intelligent, Nonmutilative Patient with Features of the Lesch-Nyhan Syndrome

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12 December 2020

Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

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12 December 2020

Supernatant rescue assay vs. polymerase chain reaction for detection of wild type adenovirus-contaminating recombinant adenovirus stocks

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12 December 2020

Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells

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12 December 2020

Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector

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12 December 2020

Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus

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12 December 2020

Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion

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12 December 2020

Purine and pyrimidine transport and phosphoribosylation and their interaction in overall uptake by cultured mammalian cells. A re-evaluation

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12 December 2020

Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease

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12 December 2020

Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer

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12 December 2020

A FAMILIAL DISORDER OF URIC ACID METABOLISM AND CENTRAL NERVOUS SYSTEM FUNCTION

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12 December 2020

Biochemical Evidence of Dysfunction of Brain Neurotransmitters in the Lesch-Nyhan Syndrome

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12 December 2020

Defects of tetrahydrobiopterin synthesis and their possible relationship to a disorder of purine metabolism (the Lesch-Nyhan syndrome).

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12 December 2020

Bone marrow transplantation in Lesch-Nyhan disease

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12 December 2020

Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors

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12 December 2020

Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

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12 December 2020

Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase activity

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12 December 2020

A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency

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12 December 2020

Mice with adenine phosphoribosyltransferase deficiency develop fatal 2,8-dihydroxyadenine lithiasis

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12 December 2020

Presynaptic dopaminergic deficits in Lesch-Nyhan disease

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12 December 2020

Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer

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12 December 2020

Expression of a retrovirus encoding human HPRT in mice

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12 December 2020

Protein measurement with the Folin phenol reagent

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12 December 2020

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

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12 December 2020

Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans

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12 December 2020

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

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12 December 2020

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

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12 December 2020

Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo

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12 December 2020

Identifiers

DOI

10.1023/A:1020728924026

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17 December 2017

Dimensions Publication ID

1019639503

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17 December 2017