(Q45874299)

English

Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.

scientific article published in December 2000

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scholarly article

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I. (English)

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Giannoukakis N

1

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

Mi Z

2

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

Rudert WA

3

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

Gambotto A

4

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

Trucco M

5

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

Robbins P

6

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

publication date

1 December 2000

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

7

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

23

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

2015-2022

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

https://scigraph.springernature.com/pub.10.1038/sj.gt.3301333

0 references

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Genetic control of autoimmune diabetes in the NOD mouse

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Molecular aspects of the etiology of type I diabetes mellitus

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Cytokines and nitric oxide in islet inflammation and diabetes

1 reference

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IL-1 produced and released endogenously within human islets inhibits beta cell function

1 reference

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21 January 2018

Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines (HIT-T15 and NIT-1) confers resistance against interleukin-1-induced nitric oxide production

1 reference

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An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1?

1 reference

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Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

1 reference

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Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release

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Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

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21 January 2018

Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus

1 reference

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21 January 2018

Mouse islet cell lysis mediated by interleukin-1-induced Fas.

1 reference

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Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro

1 reference

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Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells. Implications in thymic aging.

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Apoptosis in the pancreatic islet cells of the neonatal rat is associated with a reduced expression of insulin-like growth factor II that may act as a survival factor.

1 reference

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Insulin-like growth factor-1 (IGF-1) protects NOD mice from insulitis and diabetes

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Targeting autoimmune diabetes with gene therapy

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Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function

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Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways

1 reference

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Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

1 reference

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

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Infection of intact human islets by a lentiviral vector

1 reference

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Ex vivo adenovirus-mediated gene delivery leads to long-term expression in pancreatic islet transplants

1 reference

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21 January 2018

Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B.

1 reference

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21 January 2018

Modulation of adenovirus-mediated gene transfer by nitric oxide

1 reference

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Nitric oxide and viral infection: NO antiviral activity against a flavivirus in vitro, and evidence for contribution to pathogenesis in experimental infection in vivo

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Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

1 reference

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21 January 2018

The ontogeny of insulin-like growth factor (IGF) and IGF-binding protein gene expression in the rat pancreas.

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C-myc expression affects proliferation but not terminal differentiation or survival of explanted erythroid progenitor cells.

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Insulin-like growth factors regulate neuronal differentiation and survival.

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Growth hormone, growth factors and hematopoiesis

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The proteolytic procaspase activation network: an in vitro analysis.

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Serial killers: ordering caspase activation events in apoptosis

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Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli

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Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

1 reference

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Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

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Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.

1 reference

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21 January 2018

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1 reference

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Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism

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Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

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Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats

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IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice

1 reference

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Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs

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Somatomedin-C in human fetal pancreas. Cellular localization and release during organ culture

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Insulin-like growth factor-I prevents apoptosis in neurons after nerve growth factor withdrawal

1 reference

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Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas

1 reference

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Insulin-like growth factor I reverses interleukin-1beta inhibition of insulin secretion, induction of nitric oxide synthase and cytokine-mediated apoptosis in rat islets of Langerhans

1 reference

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Insulin-like growth factor I (IGF-I) delays the onset of diabetes in non-obese diabetic (NOD) mice

1 reference

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Direct effect of insulin and insulin-like growth factor-I on the secretory activity of rat pancreatic beta cells

1 reference

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7 January 2021

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Insulin-like growth factor I does not inhibit insulin secretion in adult human pancreatic islets in tissue culture

1 reference

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7 January 2021

based on heuristic

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IGF-I has a dual effect on insulin release from isolated, perifused adult rat islets of Langerhans

1 reference

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7 January 2021

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The role of nitric oxide in limiting gene transfer: parallels to viral host defenses

1 reference

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Nitric oxide and macrophage antiviral extrinsic activity

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Nitric oxide mediates IL-1 beta-induced islet dysfunction and destruction: prevention by dexamethasone

1 reference

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7 January 2021

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The role of the IGF-I receptor in apoptosis.

1 reference

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7 January 2021

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Type I insulin-like growth factor receptor activation regulates apoptotic proteins

1 reference

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Insulin-like growth factor-1 inhibition of apoptosis is associated with increased expression of the bcl-xL gene product

1 reference

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7 January 2021

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Synergistic action of R-Ras and IGF-1 on Bcl-xL expression and caspase-3 inhibition in BaF3 cells: R-Ras and IGF-1 control distinct anti-apoptotic kinase pathways

1 reference

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7 January 2021

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Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I

1 reference

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7 January 2021

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Improved human islet isolation using a new enzyme blend, liberase

1 reference

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7 January 2021

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Identifiers

10.1038/SJ.GT.3301333

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

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1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/11175313

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