(Q45880966)

17 December 2017

title

Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia (English)

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17 December 2017

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9

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17 December 2017

author name string

C Maiorino

1

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17 December 2017

R Khorooshi

2

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17 December 2017

F Ruffini

3

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17 December 2017

M Løbner

4

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17 December 2017

A Bergami

5

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17 December 2017

L Garzetti

6

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17 December 2017

G Martino

7

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17 December 2017

T Owens

8

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17 December 2017

publication date

2 August 2012

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

20

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17 December 2017

page(s)

487-496

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17 December 2017

issue

5

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/gt.2012.58

exact match

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cites work

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Interleukin-25 and interleukin-13 production by alveolar macrophages in response to particles

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IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells

21 January 2018

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Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB.

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Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.

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Interleukin 25 promotes the initiation of proallergic type 2 responses.

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IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo

21 January 2018

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IL-25 regulates Th17 function in autoimmune inflammation

21 January 2018

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IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice

21 January 2018

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IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease

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Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease.

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Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.

21 January 2018

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Interleukin-25 fails to activate STAT6 and induce alternatively activated macrophages.

21 January 2018

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

21 January 2018

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Alternative activation of macrophages: mechanism and functions

21 January 2018

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

21 January 2018

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Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

21 January 2018

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Cancer-related inflammation

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21 January 2018

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Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation

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Microglia in ALS: the good, the bad, and the resting

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Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta

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Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD).

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Assessing the contribution of inflammation in models of Alzheimer's disease

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Microglia in neurodegenerative disease

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Microglia and neuroprotection: from in vitro studies to therapeutic applications

21 January 2018

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21 January 2018

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IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis.

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Central Nervous System Delivery of Interleukin 4 by a Nonreplicative Herpes Simplex Type 1 Viral Vector Ameliorates Autoimmune Demyelination

21 January 2018

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IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system.

21 January 2018

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Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Microglial reactivity correlates to the density and the myelination of the anterogradely degenerating axons and terminals following perforant path denervation of the mouse fascia dentata.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

NF-kappaB-driven STAT2 and CCL2 expression in astrocytes in response to brain injury.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Population control of resident and immigrant microglia by mitosis and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Animal models of multiple sclerosis

21 January 2018

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Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.

21 January 2018

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Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

21 January 2018

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Motor evoked potentials in a mouse model of chronic multiple sclerosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

Inhibition of colitis by IL-25 associates with induction of alternatively activated macrophages

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2012.58

7 January 2021

The Cell Biology of Macrophage Activation

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.58

7 January 2021

Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronic-progressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes

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https://api.crossref.org/works/10.1038%2FGT.2012.58

7 January 2021

Central nervous system delivery of interleukin 4 by a nonreplicative herpes simplex type 1 viral vector ameliorates autoimmune demyelination

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https://api.crossref.org/works/10.1038%2FGT.2012.58

7 January 2021

Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS.

1 reference

https://api.crossref.org/works/10.1038%2FGT.2012.58

7 January 2021

Identifiers

DOI

10.1038/GT.2012.58

1 reference

17 December 2017

Dimensions Publication ID

0 references

1 reference

17 December 2017