(Q45882007)

English

Transgene expression of alpha tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor immunity

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

Transgene expression of alpha tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor immunity (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

author name string

J Xiang

1

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

M A Munegowda

2

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

Y Deng

3

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

publication date

19 December 2008

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

Cancer Gene Therapy

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

16

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

5

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

430-438

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

An endotoxin-induced serum factor that causes necrosis of tumors

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Phase I study of recombinant human tumor necrosis factor alpha in advanced malignant disease

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Recombinant Human Tumor Necrosis Factor Administered as a 24-Hour Intravenous Infusion. A Phase I and Pharmacologic Study

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Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level

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A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity

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Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28.

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A genetically engineered single-chain FV/TNF molecule possesses the anti-tumor immunoreactivity of FV as well as the cytotoxic activity of tumor necrosis factor.

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Coupling tumor necrosis factor-alpha with alphaV integrin ligands improves its antineoplastic activity

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Human TNF mutants with selective activity on the p55 receptor.

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Adenovirus-mediated TNF-alpha gene transfer induces significant tumor regression in mice

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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A survey of telomerase activity in human cancer

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Structure and function of telomeres

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Mammalian telomere dynamics: healing, fragmentation shortening and stabilization

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Human telomerase contains evolutionarily conserved catalytic and structural subunits

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hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

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TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection

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Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells

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A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells

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Engineered CD8+ cytotoxic T cells with fiber-modified adenovirus-mediated TNF-alpha gene transfection counteract immunosuppressive interleukin-10-secreting lung metastasis and solid tumors

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Genetic engineering of a recombinant fusion possessing anti-tumor F(ab')2 and tumor necrosis factor

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Adenovirus-mediated p16INK4 gene transfer significantly suppresses human breast cancer growth

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Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma

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Progress and potential for gene-based medicines

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Gene therapy. Second child in French trial is found to have leukemia

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Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter

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Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector

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Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

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Extension of life-span by introduction of telomerase into normal human cells

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Dendritic cells reconstituted with human telomerase gene induce potent cytotoxic T-cell response against different types of tumors

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In vitro anti-tumor immune response induced by dendritic cells transfected with hTERT recombinant adenovirus

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Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha)

1 reference

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A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2008.94

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TNF type 2 receptor (p75) lowers the threshold of T cell activation

1 reference

https://api.crossref.org/works/10.1038%2FCGT.2008.94

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High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma

1 reference

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Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion with high-dose tumor necrosis factor, interferon gamma, and melphalan

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Substitution of surface-exposed framework residues alters secretion of recombinant fusion protein Fv/tumor necrosis factor in Escherichia coli

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Adenovirus vectors for high-efficiency gene transfer into mammalian cells

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Review article: angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy

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Identifiers

10.1038/CGT.2008.94

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19096444

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