(Q45884040)

17 December 2017

title

High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain (English)

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17 December 2017

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6

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17 December 2017

Maria G. Castro

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17 December 2017

author name string

Lowenstein PR

1

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17 December 2017

Thomas CE

2

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17 December 2017

Umana P

3

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17 December 2017

Gerdes CA

4

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17 December 2017

Verakis T

5

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17 December 2017

Tondeur S

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17 December 2017

Klatzmann D

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17 December 2017

language of work or name

English

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publication date

1 January 2002

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17 December 2017

published in

Methods in Enzymology

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17 December 2017

volume

346

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17 December 2017

page(s)

292-311

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17 December 2017

Transfer of a foreign gene into the brain using adenovirus vectors

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Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors

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Adenovirus vectors for gene delivery

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

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Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo

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Prolonged expression and effective readministration of erythropoietin delivered with a fully deleted adenoviral vector

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7 January 2021

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

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Adenovirus gene transfer causes inflammation in the brain

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7 January 2021

Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination

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7 January 2021

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

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7 January 2021

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Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.

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7 January 2021

Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infection

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7 January 2021

Adenoviral vector-mediated gene expression in the nervous system of immunocompetent Wistar and T cell-deficient nude rats: preferential survival of transduced astroglial cells in nude rats.

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7 January 2021

Variation in the immune response to adenoviral vectors in the brain: influence of mouse strain, environmental conditions and priming

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7 January 2021

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

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7 January 2021

MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

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7 January 2021

Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors.

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7 January 2021

A model for long-term transgene expression in spinal cord regeneration studies

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Inflammatory responses and their impact on beta-galactosidase transgene expression following adenovirus vector delivery to the primate caudate nucleus

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7 January 2021

Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity

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7 January 2021

Fifty-one kilobase HSV-1 plasmid vector can be packaged using a helper virus-free system and supports expression in the rat brain

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7 January 2021

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

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7 January 2021

High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

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7 January 2021

DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle.

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7 January 2021

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7 January 2021

Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system

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7 January 2021

Targeting of tetracycline-regulatable transgene expression specifically to neuronal and glial cell populations using adenoviral vectors

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses

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7 January 2021

Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

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7 January 2021

Humoral immune responses to adenovirus vectors in the brain

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7 January 2021

Supernatant rescue assay vs. polymerase chain reaction for detection of wild type adenovirus-contaminating recombinant adenovirus stocks

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7 January 2021

Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration

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7 January 2021

Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination

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7 January 2021

Instability of adenoviral vectors during transport and its implication for clinical studies

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7 January 2021

Comparative kinetic analysis of FLP and cre recombinases: mathematical models for DNA binding and recombination.

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7 January 2021

Improved properties of FLP recombinase evolved by cycling mutagenesis

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7 January 2021

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

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7 January 2021

The immunogenicity of intracerebral virus infection depends on anatomical site.

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7 January 2021

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Identifiers

DOI

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17 December 2017

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17 December 2017