(Q45936702)

18 December 2017

title

Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase. (English)

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18 December 2017

author name string

Jez JM

series ordinal

1

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18 December 2017

Noel JP

series ordinal

2

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18 December 2017

language of work or name

English

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publication date

1 December 2000

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18 December 2017

Journal of Biological Chemistry

published in

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18 December 2017

volume

275

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18 December 2017

issue

50

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18 December 2017

page(s)

39640-39646

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18 December 2017

Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

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Tolerance and specificity of polyketide synthases

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Combinatorial biosynthesis for new drug discovery

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Fatty acid synthase, a proficient multifunctional enzyme

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Reaction mechanisms of homodimeric plant polyketide synthase (stilbenes and chalcone synthase). A single active site for the condensing reaction is sufficient for synthesis of stilbenes, chalcones, and 6'-deoxychalcones.

21 January 2018

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Enzymic Synthesis of an Aromatic Ring from Acetate Units. Partial Purification and Some Properties of Flavanone Synthase from Cell-Suspension Cultures of Petroselinum hortense

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Stress-Induced Phenylpropanoid Metabolism

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Rhizobium-legume nodulation: life together in the underground

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In vitro antimalarial activity of chalcones and their derivatives

21 January 2018

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Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis

21 January 2018

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Duplication and functional divergence in the chalcone synthase gene family of Asteraceae: evolution with substrate change and catalytic simplification.

21 January 2018

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Molecular analysis of resveratrol synthase. cDNA, genomic clones and relationship with chalcone synthase

21 January 2018

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The inducible 9, 10-dihydrophenanthrene pathway: characterization and expression of bibenzyl synthase and S-adenosylhomocysteine hydrolase

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Molecular cloning and heterologous expression of acridone synthase from elicited Ruta graveolens L. cell suspension cultures

21 January 2018

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A new pathway for polyketide synthesis in microorganisms.

21 January 2018

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Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase

21 January 2018

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Potentiometric determination of ionizations at the active site of papain

21 January 2018

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Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases

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21 January 2018

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21 January 2018

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Calculations of electrostatic interactions and pKas in the active site of Escherichia coli thioredoxin

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The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli

21 January 2018

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Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine

21 January 2018

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Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme

21 January 2018

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Reaction of Yeast Fatty Acid Synthetase with Iodoacetamide. 1. Kinetics of Inactivation and Extent of Carboxamidomethylation

21 January 2018

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Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer

21 January 2018

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Heterologous expression of an engineered biosynthetic pathway: functional dissection of type II polyketide synthase components in Streptomyces species

21 January 2018

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Structural modeling and site-directed mutagenesis of the actinorhodin beta-ketoacyl-acyl carrier protein synthase

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M008569200

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18 December 2017

PubMed ID

11006298

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18 December 2017