(Q45947203)

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Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3.

scientific article published on 30 June 2009

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1 February 2020

Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3 (English)

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1 February 2020

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Valeria Bertagnolo

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1 February 2020

Marco Marchisio

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Silvano Capitani

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1 February 2020

author name string

Paola Lanuti

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1 February 2020

Laura Pierdomenico

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Adriana Bascelli

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Eugenio Santavenere

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Lapo Alinari

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Sebastiano Miscia

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30 June 2009

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1 February 2020

1079-1089

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1 February 2020

https://scigraph.springernature.com/pub.10.1038/cr.2009.80

0 references

All children have a right to full access to treatment for cancer.

1 reference

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Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

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Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells

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Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

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Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters.

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Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia

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Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

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A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

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Municipal distribution of breast cancer mortality among women in Spain.

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Distinct function of monoclonal antibody to TRAIL-R2 as potentiator or inhibitor of the ligand TRAIL-induced apoptosis

1 reference

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21 January 2018

Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2

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Acute lymphoblastic leukemia in adults

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Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis

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21 January 2018

Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer.

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21 January 2018

Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

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21 January 2018

Expression of C-IAP1, C-IAP2 and SURVIVIN discriminates different types of lymphoid malignancies.

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21 January 2018

STAT signaling in the pathogenesis and treatment of leukemias

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Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia

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21 January 2018

Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

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21 January 2018

Differential expression of survivin in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemia

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Aberrant expression of caspase cascade regulatory genes in adult T-cell leukaemia: survivin is an important determinant for prognosis

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21 January 2018

TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells

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Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

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Expression of cellular FLICE/caspase-8 inhibitory protein is associated with malignant potential in endometrial carcinoma.

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Association of PI 3-K with tyrosine phosphorylated Vav is essential for its activity in neutrophil-like maturation of myeloid cells

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Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1

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Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer

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7 January 2021

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JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

1 reference

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7 January 2021

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Unique advantage of Janus kinase 3 as a target for selective and nontoxic immunosuppression

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7 January 2021

based on heuristic

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Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells

1 reference

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7 January 2021

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Phosphorylated Galectin-3 Mediates Tumor Necrosis Factor-related Apoptosis-inducing Ligand Signaling by Regulating Phosphatase and Tensin Homologue Deleted on Chromosome 10 in Human Breast Carcinoma Cells

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7 January 2021

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Acute lymphoblastic leukemia

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Cytotoxicity of TRAIL/anticancer drug combinations in human normal cells

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Identifiers

10.1038/CR.2009.80

1 reference

Europe PubMed Central

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1 February 2020

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1 February 2020

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