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Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.
scientific article published on 5 October 2017
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
title
Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
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1 April 2020
author
Atul Kumar
series ordinal
1
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Europe PubMed Central
PMC publication ID
5679756
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
Olawale G Raimi
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5
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Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
Miratul Muqit
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8
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5679756
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
Daan van Aalten
series ordinal
9
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PMC publication ID
5679756
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
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1 April 2020
author name string
Jevgenia Tamjar
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2
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Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
Andrew D Waddell
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3
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Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
Helen I Woodroof
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4
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Europe PubMed Central
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5679756
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
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1 April 2020
Andrew M Shaw
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6
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5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
Mark Peggie
series ordinal
7
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Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
language of work or name
English
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publication date
5 October 2017
1 reference
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Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
published in
eLife
1 reference
stated in
Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
volume
6
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Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
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PubMed Central
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24 May 2018
Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity
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Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases
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Mechanism of phospho-ubiquitin-induced PARKIN activation
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24 May 2018
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
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Ubiquitin is phosphorylated by PINK1 to activate parkin
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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
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24 May 2018
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
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PubMed Central
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24 May 2018
A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment.
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Sequence Determinants of a Specific Inactive Protein Kinase Conformation
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24 May 2018
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.
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PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
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24 May 2018
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
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24 May 2018
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
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24 May 2018
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.
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Hereditary early-onset Parkinson's disease caused by mutations in PINK1
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Identifiers
DOI
10.7554/ELIFE.29985
1 reference
stated in
Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
PMC publication ID
5679756
1 reference
stated in
Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
PubMed publication ID
28980524
1 reference
stated in
Europe PubMed Central
PMC publication ID
5679756
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28980524%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 April 2020
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