(Q45987051)

18 December 2017

title

Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model. (English)

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18 December 2017

author

Mandeep Virk

2

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18 December 2017

author name string

Farhang Alaee

1

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18 December 2017

Hezhen Tang

3

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Osamu Sugiyama

4

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Douglas J Adams

5

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Marina Stolina

6

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Denise Dwyer

7

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18 December 2017

Michael S Ominsky

8

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Hua Zhu Ke

9

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Jay R Lieberman

10

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18 December 2017

publication date

8 November 2013

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18 December 2017

Journal of Orthopaedic Research

published in

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18 December 2017

volume

32

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18 December 2017

issue

2

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18 December 2017

page(s)

197-203

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18 December 2017

Wnt pathway, an essential role in bone regeneration

cites work

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Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair.

21 January 2018

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Wnt signaling during fracture repair

21 January 2018

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The Wnt signaling pathway as a potential target for therapies to enhance bone repair.

21 January 2018

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

21 January 2018

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Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo

21 January 2018

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Wnt proteins promote bone regeneration

21 January 2018

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The health economics of the treatment of long-bone non-unions

21 January 2018

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Iliac crest bone graft harvest donor site morbidity. A statistical evaluation

21 January 2018

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Complications of posterior iliac crest bone grafting in spine surgery in children

21 January 2018

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Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies

21 January 2018

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Recombinant bone morphogenic protein-2 in orthopaedic surgery: a review

21 January 2018

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Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion

21 January 2018

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Symptomatic ectopic bone formation after off-label use of recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion

21 January 2018

1 reference

Sclerostin: current knowledge and future perspectives

21 January 2018

1 reference

First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function

21 January 2018

1 reference

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation

21 January 2018

1 reference

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

21 January 2018

1 reference

Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model.

21 January 2018

1 reference

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

21 January 2018

1 reference

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

21 January 2018

1 reference

Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.

21 January 2018

1 reference

Sclerostin in Mineralized Matrices and van Buchem Disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JOR.22498

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18 December 2017

PubMed ID

24600701

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18 December 2017