(Q46002902)

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A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes. (English)

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

author name string

Vincent A Stepanik

1

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

Peter J Harte

2

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

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11 December 2011

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

Developmental Biology

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

364

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

249-258

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

2

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Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

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Structural dynamics of protein lysine methylation and demethylation

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The polycomb group mutant esc leads to augmented levels of paused Pol II in the Drosophila embryo

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In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases

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Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

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Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP

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Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

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Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila

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Polycomb preferentially targets stalled promoters of coding and noncoding transcripts

1 reference

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Single nucleosome ChIPs identify an extensive switch of acetyl marks on cell cycle promoters

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The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family.

1 reference

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Trithorax: A new homoeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments

1 reference

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The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax

1 reference

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Histone modification levels are predictive for gene expression

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Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization

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Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes

1 reference

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The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins

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A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities

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Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent

1 reference

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Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

1 reference

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dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

1 reference

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Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

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Role of the polycomb protein EED in the propagation of repressive histone marks

1 reference

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The Polycomb complex PRC2 and its mark in life

1 reference

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The role of polycomb group proteins in cell cycle regulation during development

1 reference

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Histone replacement marks the boundaries of cis-regulatory domains

1 reference

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

1 reference

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Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

1 reference

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Chromosomal distribution of PcG proteins during Drosophila development

1 reference

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A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC

1 reference

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Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins

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Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene

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Control of the initiation of homeotic gene expression by the gap genes giant and tailless in Drosophila.

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The Drosophila extra sex combs protein contains WD motifs essential for its function as a repressor of homeotic genes.

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Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae.

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Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

1 reference

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Histone methylation by PRC2 is inhibited by active chromatin marks

1 reference

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Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos

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Genome-wide analysis of Polycomb targets in Drosophila melanogaster

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Polycomb silencing mechanisms and the management of genomic programmes

1 reference

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Stabilization of chromatin structure by PRC1, a Polycomb complex

1 reference

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Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

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Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II.

1 reference

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

1 reference

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CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.

1 reference

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A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3

1 reference

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The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.

1 reference

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Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

1 reference

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The polycomb group protein EZH2 is involved in progression of prostate cancer

1 reference

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1 reference

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Histone methyltransferase G9a contributes to H3K27 methylation in vivo

1 reference

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Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions

1 reference

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Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase

1 reference

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Structural basis for the product specificity of histone lysine methyltransferases

1 reference

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7 January 2021

Identifiers

10.1016/J.YDBIO.2011.12.007

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

1 reference

Europe PubMed Central

18 December 2017

http://europepmc.org/abstract/MED/22182520

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