(Q46029896)

18 December 2017

title

The evolutionarily conserved residue A653 plays a key role in HERG channel closing. (English)

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18 December 2017

author

Jens Meiler

5

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18 December 2017

author name string

Svetlana Z Stepanovic

1

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18 December 2017

Franck Potet

2

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18 December 2017

Christina I Petersen

3

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18 December 2017

Jarrod A Smith

4

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18 December 2017

Jeffrey R Balser

6

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18 December 2017

Sabina Kupershmidt

7

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18 December 2017

language of work or name

English

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publication date

30 April 2009

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18 December 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

Journal of Physiology

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18 December 2017

volume

587

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18 December 2017

issue

Pt 11

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18 December 2017

page(s)

2555-2566

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18 December 2017

Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis

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A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating

21 January 2018

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The S4-S5 linker couples voltage sensing and activation of pacemaker channels.

21 January 2018

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Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

21 January 2018

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

21 January 2018

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Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers.

21 January 2018

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Investigating the putative glycine hinge in Shaker potassium channel.

21 January 2018

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

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A new oral therapy for long QT syndrome: long-term oral potassium improves repolarization in patients with HERG mutations

21 January 2018

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Physicochemical features of the HERG channel drug binding site

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Molecular determinants of dofetilide block of HERG K+ channels.

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

A cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

The open pore conformation of potassium channels

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

X-ray structure of a voltage-dependent K+ channel

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Molecular determinants of HERG channel block.

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide.

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca2+-activated K+ (BKCa) channels

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

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Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

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Ion conduction pore is conserved among potassium channels

21 January 2018

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Coupling between voltage sensors and activation gate in voltage-gated K+ channels

21 January 2018

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Modeling the hERG potassium channel in a phospholipid bilayer: Molecular dynamics and drug docking studies

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

A structural basis for drug-induced long QT syndrome

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

UCSF Chimera--a visualization system for exploratory research and analysis

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

The domain and conformational organization in potassium voltage-gated ion channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis

21 January 2018

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Genetics of acquired long QT syndrome

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Modeling structurally variable regions in homologous proteins with rosetta.

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Structural models for the KCNQ1 voltage-gated potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

The inward rectification mechanism of the HERG cardiac potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

21 January 2018

I(Kr): the hERG channel

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Comparison of kinetic properties of quinidine and dofetilide block of HERG channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2008.166694

Structural determinants for high-affinity block of hERG potassium channels.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

Conserved gating hinge in ligand- and voltage-dependent K+ channels

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

I Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

29 September 2018

Voltage-gated K channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

Block of an ether-a-go-go-like K(+) channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2714020

10.1113/JPHYSIOL.2008.166694

29 September 2018

Identifiers

DOI

1 reference

18 December 2017

PMC publication ID

2714020

0 references

1 reference

18 December 2017