(Q46036396)

18 December 2017

title

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. (English)

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18 December 2017

author name string

Bansal-Pakala P

series ordinal

1

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18 December 2017

Jember AG

series ordinal

2

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18 December 2017

Croft M

series ordinal

3

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18 December 2017

language of work or name

English

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publication date

1 August 2001

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18 December 2017

published in

Nature Medicine

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18 December 2017

volume

7

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18 December 2017

page(s)

907-912

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18 December 2017

issue

8

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18 December 2017

https://scigraph.springernature.com/pub.10.1038/90942

exact match

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cites work

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance

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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

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Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

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Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

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Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

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OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection

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Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

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Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion

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Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

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Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

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OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

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A cell culture model for T lymphocyte clonal anergy

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Immunological activity of covalently linked T-cell epitopes

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In vivo induction of tolerance in murine CD4+ cell subsets

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T cell priming versus T cell tolerance induced by synthetic peptides

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Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

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Engagement of the OX-40 receptor in vivo enhances antitumor immunity

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Role of antigen-presenting cells in mediating tolerance and autoimmunity

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CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism

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CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

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7 January 2021

Transactivation by AP-1 is a molecular target of T cell clonal anergy

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7 January 2021

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors

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7 January 2021

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

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7 January 2021

4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

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7 January 2021

Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation

1 reference

7 January 2021

Identifiers

DOI

10.1038/90942

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18 December 2017

PubMed ID

11479622

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18 December 2017