(Q46041523)

English

5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones

scientific article published on 4 March 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

3

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

author name string

Andrew J Smith

1

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

Robert A Smith

2

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

publication date

4 March 2009

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

Neurotoxicity Research

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

15

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

4

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

303-310

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic acid with molecular oxygen

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9034-0

21 January 2018

Tryptophan degradation in autoimmune diseases

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9034-0

21 January 2018

Proinflammatory cytokines and apoptosis following glutamate-induced excitotoxicity mediated by p38 MAPK in the hippocampus of neonatal rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction†

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous kynurenines as targets for drug discovery and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death in rat cerebellar granule neurons induced by hydrogen peroxide in vitro: mechanisms and protection by adenosine receptor ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage in Huntington's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tryptophan metabolism and oxidative stress in patients with chronic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity of tryptophan metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolinic acid induces NMDA receptor-mediated lipid peroxidation in rat brain microvessels

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic denervation enhances susceptibility to hydroxyl radicals in rat neostriatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolinic acid induces oxidative stress in rat brain synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tryptophan metabolism and oxidative stress in patients with Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and electrophysiological correlates of the quinolinic acid rat model of Huntington's disease in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KYNURENINE PATHWAY METABOLISM IN PATIENTS WITH OSTEOPOROSIS AFTER 2 YEARS OF DRUG TREATMENT

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species induce different cell death mechanisms in cultured neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19384564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12640-009-9034-0

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19384564

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