(Q46056361)

19 December 2017

title

Connections of nicotine to cancer (English)

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19 December 2017

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Sergei A Grando

1

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19 December 2017

language of work or name

English

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publication date

15 May 2014

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19 December 2017

published in

Nature Reviews Cancer

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19 December 2017

volume

14

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19 December 2017

issue

6

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19 December 2017

page(s)

419-429

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19 December 2017

https://scigraph.springernature.com/pub.10.1038/nrc3725

exact match

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cites work

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Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance

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Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer

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Nicotinic acetylcholine receptor signaling in tumor growth and metastasis

31 March 2020

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Role of nicotine in gallbladder carcinoma: a preliminary report

31 March 2020

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Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.

31 March 2020

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Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia

31 March 2020

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Nicotinic receptor and tobacco-related cancer.

31 March 2020

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Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population

31 March 2020

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Is susceptibility locus for lung cancer in the 15q25 nicotinic acetylcholine receptor gene cluster CHRNA5-A3-B4 associated with risk of gastric cancer?

31 March 2020

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Systematic review of the relation between smokeless tobacco and cancer in Europe and North America

31 March 2020

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Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway

31 March 2020

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Metabolism and disposition kinetics of nicotine

31 March 2020

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Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines

31 March 2020

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Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells

31 March 2020

1 reference

The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells

31 March 2020

1 reference

Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptors

31 March 2020

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Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: implications on lung carcinogenesis.

31 March 2020

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Nicotine induces DNA damage in human salivary glands

31 March 2020

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Assessment of nicotine-induced DNA damage in a genotoxicological test battery

31 March 2020

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Analysis of nicotine-induced DNA damage in cells of the human respiratory tract

31 March 2020

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Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine

31 March 2020

1 reference

Biomembrane permeation of nicotine: mechanistic studies with porcine mucosae and skin

31 March 2020

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A mechanistic analysis to characterize oramucosal permeation properties

31 March 2020

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Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro: effect of pH and concentration

31 March 2020

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Transport mechanisms of nicotine across the human intestinal epithelial cell line Caco-2.

31 March 2020

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Comparison of pure nicotine- and smokeless tobacco extract-induced toxicities and oxidative stress

31 March 2020

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Genotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts

31 March 2020

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K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors

31 March 2020

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How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

31 March 2020

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Rhabdomyosarcomas in aging A/J mice

31 March 2020

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A study of tobacco carcinogenesis. XLII. Bioassay in A/J mice of some structural analogues of tobacco-specific nitrosamines

31 March 2020

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Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells

31 March 2020

1 reference

Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy

31 March 2020

1 reference

The nicotinic acetylcholine receptor: structure and autoimmune pathology

31 March 2020

1 reference

Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes

31 March 2020

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Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic receptors in monkey striatum

31 March 2020

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Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers

31 March 2020

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Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

31 March 2020

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Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells

31 March 2020

1 reference

Receptor-mediated tobacco toxicity: regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells

31 March 2020

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Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes

31 March 2020

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Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke

31 March 2020

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Nicotine promotes tumor growth and metastasis in mouse models of lung cancer

31 March 2020

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Regulatory role of the α7nAChR in cancer

31 March 2020

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Expression of voltage-gated calcium channel subunit alpha1C in epidermal keratinocytes and effects of agonist and antagonists of the channel on skin barrier homeostasis.

31 March 2020

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Ca2+ permeability of nicotinic acetylcholine receptors

31 March 2020

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Ca2+ permeability through rat cloned alpha9-containing nicotinic acetylcholine receptors

31 March 2020

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Inability of Ca2+ influx through nicotinic ACh receptor channels to stimulate catecholamine secretion in bovine adrenal chromaffin cells: studies with fura-2 and SBFI microfluorometry

31 March 2020

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The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration

31 March 2020

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Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes

31 March 2020

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Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization

31 March 2020

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Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells

31 March 2020

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Mitogen-activated protein kinase pathway was significantly activated in human bronchial epithelial cells by nicotine.

31 March 2020

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Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating α7AChR, ERK, HIF-1α and VEGF/PEDF signaling

31 March 2020

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Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth

31 March 2020

1 reference

Receptor-mediated tobacco toxicity: alterations of the NF-kappaB expression and activity downstream of alpha7 nicotinic receptor in oral keratinocytes

31 March 2020

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Coupling of ionic events to protein kinase signaling cascades upon activation of alpha7 nicotinic receptor: cooperative regulation of alpha2-integrin expression and Rho kinase activity

31 March 2020

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Phosphotyrosine phosphatase activity associated with c-Src in large multimeric complexes isolated from adrenal medullary chromaffin cells.

31 March 2020

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Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

31 March 2020

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alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity

31 March 2020

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Regulation of the neuronal nicotinic acetylcholine receptor by SRC family tyrosine kinases

31 March 2020

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Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits.

31 March 2020

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Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways

31 March 2020

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Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis.

31 March 2020

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Lung carcinoma signaling pathways activated by smoking

31 March 2020

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Nicotinic acetylcholine receptors and the regulation of neuronal signalling.

31 March 2020

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Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers

31 March 2020

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Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line

31 March 2020

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Microarray analysis of nicotine-induced changes in gene expression in a macrophage-like human cell line

31 March 2020

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Cholinergic control of epidermal cohesion

31 March 2020

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A receptor-mediated mechanism of nicotine toxicity in oral keratinocytes

31 March 2020

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Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study

31 March 2020

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Intervention of nicotine on MNU-induced bladder cancer in rats.

31 March 2020

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Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways.

31 March 2020

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β-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice

31 March 2020

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Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma

31 March 2020

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Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway

31 March 2020

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Chronic nicotine treatment up-regulates human alpha3 beta2 but not alpha3 beta4 acetylcholine receptors stably transfected in human embryonic kidney cells

31 March 2020

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Nicotine at a low concentration promotes wound healing

31 March 2020

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Treating a collagen scaffold with a low concentration of nicotine promoted angiogenesis and wound healing

31 March 2020

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Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice

31 March 2020

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Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by α7 nicotinic receptor agonist.

31 March 2020

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Cellular and molecular mechanisms of nicotine's pro-angiogenesis activity and its potential impact on cancer

31 March 2020

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Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation.

31 March 2020

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Nicotine-induced fibroblast growth factor-2 restores the age-related decline of precursor cell proliferation in the subventricular zone of rat brain.

31 March 2020

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Change in nicotine-induced VEGF, PGE2 AND COX-2 expression following COX inhibition in human oral squamous cancer

31 March 2020

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Increased tyrosine phosphorylation and novel cis-acting element mediate activation of the fibroblast growth factor-2 (FGF-2) gene by nicotinic acetylcholine receptor. New mechanism for trans-synaptic regulation of cellular development and plasticity

31 March 2020

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MG624, an α7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway

31 March 2020

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Induction of acetylcholine receptor cluster formation by local application of growth factors in cultured Xenopus muscle cells

31 March 2020

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The influence of basic fibroblast growth factor on acetylcholine receptors in cultured muscle cells

31 March 2020

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Nicotine Regulates Basic Fibroblastic Growth Factor and Transforming Growth Factor β1Production in Endothelial Cells

31 March 2020

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Nicotine-induced smooth muscle cell proliferation is mediated through bFGF and TGF-β1

31 March 2020

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Role of transforming growth factor-beta signaling in cancer

31 March 2020

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Nicotine enhances proliferation, migration, and radioresistance of human malignant glioma cells through EGFR activation.

31 March 2020

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Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces α9-nicotinic acetylcholine receptor expression in human breast cancer cells

31 March 2020

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Neurotransmission and cancer: implications for prevention and therapy

31 March 2020

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Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent

31 March 2020

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Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K/Akt pathway.

31 March 2020

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Nicotinic modulation of therapeutic response in vitro and in vivo

31 March 2020

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Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs.

31 March 2020

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Nicotine induces resistance to chemotherapy in nasal epithelial cancer

31 March 2020

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Chronic nicotine inhibits the therapeutic effects of gemcitabine on pancreatic cancer in vitro and in mouse xenografts

31 March 2020

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Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria

31 March 2020

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Intracellular localization of nicotinic acetylcholine receptors in human cell lines.

31 March 2020

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α7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways.

31 March 2020

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Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons

31 March 2020

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α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling

31 March 2020

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Biochemical physiology of central synapses

31 March 2020

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ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors

31 March 2020

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Role of ?7-Nicotinic Acetylcholine Receptor in Normal and Cancer Stem Cells

31 March 2020

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Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility

31 March 2020

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Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma

31 March 2020

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Nicotine promotes acquisition of stem cell and epithelial-to-mesenchymal properties in head and neck squamous cell carcinoma

31 March 2020

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Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells

31 March 2020

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Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation

31 March 2020

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Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines

31 March 2020

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Nicotine enhances colon cancer cell migration by induction of fibronectin.

31 March 2020

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Nicotine: a pro-angiogenic factor.

31 March 2020

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Nicotine and pathological angiogenesis

31 March 2020

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Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

31 March 2020

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A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion

31 March 2020

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Tumor evasion from T cell surveillance

31 March 2020

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Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination

31 March 2020

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Transdermal nicotine inhibits interleukin 2 synthesis by mononuclear cells derived from healthy volunteers

31 March 2020

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Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis

31 March 2020

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Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naïve CD4 T cells toward the Th1, Th2 and Th17 lineages

31 March 2020

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Immune surveillance: a balance between protumor and antitumor immunity

31 March 2020

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Nicotinic receptor β2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer.

31 March 2020

1 reference

Natural killer cells in human cancer: from biological functions to clinical applications

31 March 2020

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Nicotinic acetylcholine receptors mediate lung cancer growth

31 March 2020

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Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors

31 March 2020

1 reference

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced α9-nicotinic acetylcholine receptor upregulation in human breast cancer cells.

31 March 2020

1 reference

Targeting alpha7-nicotinic receptor for the treatment of pleural mesothelioma.

31 March 2020

1 reference

Natural agents targeting the alpha7-nicotinic-receptor in NSCLC: a promising prospective in anti-cancer drug development

31 March 2020

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Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment

31 March 2020

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Inhibition of non-neuronal alpha7-nicotinic receptor reduces tumorigenicity in A549 NSCLC xenografts

31 March 2020

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Nicotine monitoring in sweat with a sweat patch

31 March 2020

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31 March 2020

1 reference

Smoking habits in patients with inflammatory bowel disease

31 March 2020

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The recurrent aphthous stomatitis frequency in the smoking cessation people

31 March 2020

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Low-dose smoking resumption in ex-smokers with refractory ulcerative colitis.

31 March 2020

1 reference

Transdermal nicotine for active ulcerative colitis.

31 March 2020

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Nicotine replacement therapy as a treatment for complex aphthosis

31 March 2020

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Nicotine patches for aphthous ulcers due to Behçet's syndrome

31 March 2020

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Successful treatment of digital ulceration in Buerger's disease with nicotine chewing gum.

31 March 2020

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Successful treatment of pyoderma gangrenosum with nicotine chewing gum

31 March 2020

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Nicotine for pyoderma gangrenosum

31 March 2020

1 reference

Could nicotine be beneficial for Behçet's disease?

31 March 2020

1 reference

Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems.

31 March 2020

1 reference

The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans

31 March 2020

1 reference

Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study

31 March 2020

1 reference

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

31 March 2020

1 reference

Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese

31 March 2020

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Association of smoking with tumor size at diagnosis in non-small cell lung cancer

31 March 2020

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Correlation between polymorphisms of nicotine acetylcholine acceptor subunit CHRNA3 and lung cancer susceptibility

31 March 2020

1 reference

A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk

31 March 2020

1 reference

[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]

31 March 2020

1 reference

Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation

31 March 2020

1 reference

Functionally significant nicotine acetylcholine receptor subunit α5 promoter haplotypes are associated with susceptibility to lung cancer in Chinese

31 March 2020

1 reference

Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases.

31 March 2020

1 reference

31 March 2020

Nicotine and lung cancer

1 reference

Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation

31 March 2020

1 reference

12 December 2020

alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors

1 reference

12 December 2020

The effect of cotinine on telomerase activity in human vascular smooth muscle cells.

1 reference

12 December 2020

Distinct characteristics of transcellular transport between nicotine and tetraethylammonium in LLC-PK1 cells.

1 reference

12 December 2020

Receptor-mediated inhibition of keratinocyte migration by nicotine involves modulations of calcium influx and intracellular concentration

1 reference

12 December 2020

Mechanisms for nicotine in the development and progression of gastrointestinal cancers

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12 December 2020

Smoking and inflammatory bowel disease

1 reference

12 December 2020

The role of skin nociceptive afferent nerves in blister healing.

1 reference

12 December 2020

Effect of acetylcholine on the cytotoxicity of natural killer cells

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12 December 2020

Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma

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12 December 2020

Nicotine, through upregulating pro-survival signaling, cooperates with NNK to promote transformation

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12 December 2020

Interaction of nicotine with anticancer treatment.

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12 December 2020

Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine.

1 reference

12 December 2020

The therapeutic effect of cigarette smoking on oral/genital aphthosis and other manifestations of Behçet's disease

1 reference

12 December 2020

Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells

1 reference

12 December 2020

Modification of acetylcholine action by bivalent cations on the perfused heart of the frog

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12 December 2020

[Adverse effects of Swedish smokeless tobacco "snus"].

1 reference

12 December 2020

Nicotine has implications in different tumors types. Expert's eye making a literature analysis

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12 December 2020

Nicotine enhances neovascularization and promotes tumor growth

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12 December 2020

Role of α7-nicotinic acetylcholine receptor in normal and cancer stem cells

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12 December 2020

Effect of acetylcholine on in vitro IL-2 production and NK cell cytotoxicity of rats.

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12 December 2020

Identifiers

DOI

10.1038/NRC3725

1 reference

19 December 2017

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19 December 2017