(Q46070690)

19 December 2017

title

The Neurotoxin l-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine (MPTP): A Key to Parkinson's Disease? (English)

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19 December 2017

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I Irwin

1

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19 December 2017

publication date

1 February 1986

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19 December 2017

published in

Pharmaceutical Research

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19 December 2017

volume

3

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19 December 2017

issue

1

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19 December 2017

page(s)

7-11

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19 December 2017

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

cites work

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12 December 2020

Deprenyl (selegiline) in the treatment of Parkinson's disease

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12 December 2020

Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice

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12 December 2020

Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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12 December 2020

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine destroys dopamine neurons in explants of rat embryo mesencephalon

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12 December 2020

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

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12 December 2020

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

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12 December 2020

Distinct monoamine oxidase A and B populations in primate brain

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12 December 2020

Selective accumulation of MPP+ in the substantia nigra: a key to neurotoxicity?

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12 December 2020

Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro

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12 December 2020

Neurochemical and behavioral effects of systematic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat

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12 December 2020

Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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12 December 2020

Neurochemical and histochemical characterization of neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurones in the mouse

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12 December 2020

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

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12 December 2020

MPTP neurotoxicity: an overview and characterization of phases of toxicity

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12 December 2020

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

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12 December 2020

Trail of ironies to Parkinson's disease

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12 December 2020

Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys

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12 December 2020

(-)-Deprenyl leads to prolongation of L-dopa efficacy in Parkinson's disease

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12 December 2020

Redox delivery system for brain-specific, sustained release of dopamine

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12 December 2020

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

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12 December 2020

Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum

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12 December 2020

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

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12 December 2020

The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence

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12 December 2020

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

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12 December 2020

Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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12 December 2020

Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP

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12 December 2020

Brain enzyme is the target of drug toxin

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12 December 2020

Aetiology of Parkinson's disease

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12 December 2020

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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12 December 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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12 December 2020

Piperidine derivatives. Part III. 4-arylpiperidines

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12 December 2020

Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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12 December 2020

Identifiers

DOI

10.1023/A:1016312629652

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19 December 2017

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19 December 2017