(Q46074716)

19 December 2017

http://europepmc.org/abstract/MED/19321774

title

The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore (English)

1 reference

19 December 2017

http://europepmc.org/abstract/MED/19321774

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

Christopher A Reid

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

Kim L Powell

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

author name string

Megan L Smart

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

David A Williams

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

language of work or name

English

0 references

publication date

1 March 2009

1 reference

19 December 2017

http://europepmc.org/abstract/MED/19321774

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

page(s)

3781-3791

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

Cytolytic P2X purinoceptors.

15 May 2020

cites work

1 reference

12 December 2020

Reactive microgliosis

1 reference

12 December 2020

A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes

1 reference

12 December 2020

Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease

1 reference

12 December 2020

Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation

1 reference

12 December 2020

Two different ionotropic receptors are activated by ATP in rat microglia

1 reference

12 December 2020

Dynamic selectivity filters in ion channels

1 reference

12 December 2020

Gain of function mutants: ion channels and G protein-coupled receptors

1 reference

12 December 2020

Altered cytokine production in mice lacking P2X(7) receptors

1 reference

12 December 2020

Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods

1 reference

12 December 2020

ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma

1 reference

12 December 2020

[Microglia: origin and development]

1 reference

12 December 2020

Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity.

1 reference

12 December 2020

Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems

1 reference

12 December 2020

Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease.

1 reference

12 December 2020

The P2X(7) receptor from Xenopus laevis: formation of a large pore in Xenopus oocytes

1 reference

12 December 2020

Stimulation of Ca(2+) influx through ATP receptors on rat brain synaptosomes: identification of functional P2X(7) receptor subtypes

1 reference

12 December 2020

Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus

1 reference

12 December 2020

Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration

1 reference

12 December 2020

Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase.

1 reference

12 December 2020

Extracellular ATP and P2X7 receptors in neurodegeneration

1 reference

12 December 2020

Prospects for rational development of pharmacological gap junction channel blockers

1 reference

12 December 2020

P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region

1 reference

12 December 2020

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Increased morphological diversity of microglia in the activated hypothalamic supraoptic nucleus.

1 reference

12 December 2020

Differential co-localisation of the P2X7 receptor subunit with vesicular glutamate transporters VGLUT1 and VGLUT2 in rat CNS.

1 reference

12 December 2020

Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia.

1 reference

12 December 2020

Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes

1 reference

12 December 2020

High Ca(2+)-phosphate transfection efficiency enables single neuron gene analysis

1 reference

12 December 2020

P2X7 receptor inhibition improves recovery after spinal cord injury

1 reference

12 December 2020

Microglia and neuroinflammation: a pathological perspective

1 reference

12 December 2020

Effects of carbenoxolone on alveolar fluid clearance and lung inflammation in the rat.

1 reference

12 December 2020

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

1 reference

12 December 2020

Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin

1 reference

12 December 2020

A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion

1 reference

12 December 2020

Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration

1 reference

12 December 2020

Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner.

1 reference

12 December 2020

Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus

1 reference

12 December 2020

Gap junction hemichannel-mediated release of glutathione from cultured rat astrocytes

1 reference

12 December 2020

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex

1 reference

12 December 2020

Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain.

1 reference

12 December 2020

Cellular localization of P2X7 receptor mRNA in the rat brain

1 reference

12 December 2020

Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors

1 reference

12 December 2020

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

1 reference

12 December 2020

Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo

1 reference

12 December 2020

Interleukin 1 is processed and released during apoptosis

1 reference

12 December 2020

New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury

1 reference

12 December 2020

ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.

1 reference

12 December 2020

Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid

1 reference

12 December 2020

ATP induces nucleotide permeability in rat mast cells

1 reference

12 December 2020

Microglia: Intrinsic immuneffector cell of the brain

1 reference

12 December 2020

Co-release of noradrenaline and ATP from cultured sympathetic neurons.

1 reference

12 December 2020

Cytotoxicity of microglia

1 reference

12 December 2020

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor

1 reference

12 December 2020

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

1 reference

12 December 2020

Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin

1 reference

12 December 2020

Nonuniform distribution of Ca2+ channel subtypes on presynaptic terminals of excitatory synapses in hippocampal cultures

1 reference

12 December 2020

Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis

1 reference

12 December 2020

Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia

1 reference

12 December 2020

Tissue distribution of the P2X7 receptor

1 reference

12 December 2020

Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease

1 reference

12 December 2020

Receptors for purines and pyrimidines

1 reference

12 December 2020

Development of microglia in the postnatal rat hippocampus

1 reference

12 December 2020

Mechanisms of cell death in Alzheimer disease--immunopathology.

1 reference

12 December 2020

Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro

1 reference

12 December 2020

Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's disease

1 reference

12 December 2020

Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease

1 reference

12 December 2020

10.1523/JNEUROSCI.5512-08.2009

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6665035&resulttype=core&format=json

15 May 2020

1 reference