(Q46109982)

English

Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools

scientific article published on 8 January 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Amelioration of cognitive deficits in plaque-bearing Alzheimer's disease model mice through selective reduction of nascent soluble Aβ42 without affecting other Aβ pools (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Alzheimer's disease

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selective reduction

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based on heuristic

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author name string

Yasuyuki Mitani

1

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Junko Yarimizu

2

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Hiroki Akashiba

3

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Yoshitsugu Shitaka

4

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Keni Ni

5

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Nobuya Matsuoka

6

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

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publication date

8 January 2013

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Journal of Neurochemistry

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

125

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

3

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

465-472

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

1 reference

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21 January 2018

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Piperidine-derived gamma-secretase modulators

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12125

21 January 2018

Identifiers

10.1111/JNC.12125

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/23240999

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