(Q46110468)

19 December 2017

title

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase (English)

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19 December 2017

author name string

Monia BP

1

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19 December 2017

Johnston JF

2

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19 December 2017

Geiger T

3

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19 December 2017

Muller M

4

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19 December 2017

Fabbro D

5

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19 December 2017

language of work or name

English

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publication date

1 June 1996

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19 December 2017

published in

Nature Medicine

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19 December 2017

volume

2

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19 December 2017

page(s)

668-675

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19 December 2017

issue

6

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19 December 2017

https://scigraph.springernature.com/pub.10.1038/nm0696-668

exact match

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cites work

The ins and outs of Raf kinases

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The MAP kinase cascade is essential for diverse signal transduction pathways

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

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The ras gene family and human carcinogenesis

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Mutational activation of c-raf-1 and definition of the minimal transforming sequence

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Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences

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Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

21 January 2018

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Isolation of a transforming sequence from a human bladder carcinoma cell line

21 January 2018

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Oligonucleotide sequences required for natural killer cell activation

21 January 2018

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Lipofection of synthetic oligodeoxyribonucleotide having a palindromic sequence of AACGTT to murine splenocytes enhances interferon production and natural killer activity

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Diversity in function and regulation of MAP kinase pathways

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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

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Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

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7 January 2021

Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer

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Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice

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The state of the art in antisense research

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Does antisense exist?

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Therapeutic Applications of Oligonucleotides

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Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection

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7 January 2021

Breast tumor cell lines from pleural effusions

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7 January 2021

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides

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Heterologous protection against influenza by injection of DNA encoding a viral protein

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Complementary oligonucleotide binding to transfer RNA

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Binding of complementary oligoribonucleotides to yeast initiator transfer RNA

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7 January 2021

Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site

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7 January 2021

Implication of RNA structure on antisense oligonucleotide hybridization kinetics

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7 January 2021

DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth

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7 January 2021

Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene

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https://api.crossref.org/works/10.1038%2FNM0696-668

7 January 2021

Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene

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https://api.crossref.org/works/10.1038%2FNM0696-668

7 January 2021

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity

1 reference

https://api.crossref.org/works/10.1038%2FNM0696-668

7 January 2021

Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNM0696-668

7 January 2021

Identifiers

DOI

10.1038/NM0696-668

1 reference

19 December 2017

PubMed ID

8640558

1 reference

19 December 2017