(Q46114334)

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Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation

scientific article published on 16 August 2011

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

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author name string

Sejal Gandhi

1

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Da Ren

2

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Gang Xiao

3

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Pavel Bondarenko

4

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Christopher Sloey

5

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Margaret Speed Ricci

6

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Sampathkumar Krishnan

7

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

publication date

16 August 2011

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Pharmaceutical Research

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

29

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

1

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

209-224

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

Heterogeneity of monoclonal antibodies

1 reference

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Instability, stabilization, and formulation of liquid protein pharmaceuticals

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Stability of protein pharmaceuticals

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Deamidation: a source of microheterogeneity in pharmaceutical proteins

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Isoaspartate in peptides and proteins: formation, significance, and analysis

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Cation exchange-HPLC and mass spectrometry reveal C-terminal amidation of an IgG1 heavy chain.

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Protein variant separations using cation exchange chromatography on grafted, polymeric stationary phases

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Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

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Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization.

1 reference

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Effect of 'pH' on the rate of asparagine deamidation in polymeric formulations: 'pH'-rate profile

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The effects of alpha-helix on the stability of Asn residues: deamidation rates in peptides of varying helicity

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Prediction of protein deamidation rates from primary and three-dimensional structure

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Effects of acidic N + 1 residues on asparagine deamidation rates in solution and in the solid state

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Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

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Hydrophobic interaction chromatography of soluble interleukin I receptor type II to reveal chemical degradations resulting in loss of potency

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Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies

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Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H(2)(18)O.

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Prediction of low-energy collision-induced dissociation spectra of peptides

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De novo peptide sequencing based on a divide-and-conquer algorithm and peptide tandem spectrum simulation

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Large-scale identification and quantification of covalent modifications in therapeutic proteins

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Isomerization of a single aspartyl residue of anti-epidermal growth factor receptor immunoglobulin gamma2 antibody highlights the role avidity plays in antibody activity

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Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution

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Detection and quantitation of IgG 1 hinge aspartate isomerization: a rapid degradation in stressed stability studies.

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Identification and measurement of isoaspartic acid formation in the complementarity determining region of a fully human monoclonal antibody

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Investigation of degradation processes in IgG1 monoclonal antibodies by limited proteolysis coupled with weak cation-exchange HPLC.

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A study in glycation of a therapeutic recombinant humanized monoclonal antibody: where it is, how it got there, and how it affects charge-based behavior

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Molecular clocks

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Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?

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21 January 2018

Asparagine deamidation: a regulatory hourglass

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21 January 2018

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.

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Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

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12 December 2020

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Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide

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Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states

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Capillary isoelectric focusing and high-performance cation-exchange chromatography compared for qualitative and quantitative analysis of hemoglobin variants

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Protein variant separations by cation-exchange chromatography on tentacle-type polymeric stationary phases

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Deamidation and isoaspartate formation during in vitro aging of recombinant tissue plasminogen activator.

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Determination of the origin of charge heterogeneity in a murine monoclonal antibody

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Identification of multiple sources of charge heterogeneity in a recombinant antibody.

1 reference

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Chemical pathways of peptide degradation. III. Effect of primary sequence on the pathways of deamidation of asparaginyl residues in hexapeptides

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1 reference

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10.1007/S11095-011-0536-0

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

release_jrbvi2bxonerlkxgs6wnpbbnr4

1 reference

https://api.fatcat.wiki/v0/release/jrbvi2bxonerlkxgs6wnpbbnr4

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21845507

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