(Q46137779)

19 December 2017

title

The azulene framework as a novel arene bioisostere: design of potent dopamine D4 receptor ligands inducing penile erection (English)

1 reference

19 December 2017

author

Nuska Tschammer

2

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19 December 2017

Peter Gmeiner

6

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19 December 2017

author name string

Stefan Löber

1

1 reference

19 December 2017

Harald Hübner

3

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19 December 2017

Maria Rosaria Melis

4

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19 December 2017

Antonio Argiolas

5

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19 December 2017

publication date

1 March 2009

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19 December 2017

published in

ChemMedChem

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19 December 2017

volume

4

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19 December 2017

issue

3

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19 December 2017

page(s)

325-328

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19 December 2017

Bioisosterism: a useful strategy for molecular modification and drug design

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Dopamine D4 receptors elevated in schizophrenia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere This work was supported by the Fonds der Chemischen Industrie

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Synthesis and antioxidant activity of 3-substituted guaiazulene derivatives

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Synthesis of azulene, a blue hydrocarbon

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800395

7 January 2021

Identifiers

DOI

10.1002/CMDC.200800395

1 reference

19 December 2017

release_tcwtdififrb2lfynta4xydxxt4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tcwtdififrb2lfynta4xydxxt4

24 November 2022

mapped directly with Wikidata item

1 reference

19 December 2017