(Q46152278)

English

A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

scientific article published on 22 November 2013

In more languages

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scholarly article

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors (English)

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

author name string

D S Hong

1

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

R Kurzrock

2

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

A Naing

3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

J J Wheler

4

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

G S Falchook

5

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

J S Schiffman

6

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

N Faulkner

7

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

M J Pilat

8

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

J O'Brien

9

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

P LoRusso

10

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

publication date

22 November 2013

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

Investigational New Drugs

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

32

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

436-444

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

https://scigraph.springernature.com/pub.10.1007/s10637-013-0046-5

0 references

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

The spliceosome as target for anticancer treatment

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

Phase I clinical trial design in cancer drug development.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13).

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11)

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

1 reference

https://api.crossref.org/works/10.1007%2FS10637-013-0046-5

21 January 2018

SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/24258465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated titration designs for phase I clinical trials in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/24258465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/24258465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-013-0046-5

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/24258465

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