(Q46228118)

20 December 2017

title

Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). (English)

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20 December 2017

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J H Wen

1

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20 December 2017

Y Y Chen

2

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20 December 2017

S J Song

3

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20 December 2017

J Ding

4

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20 December 2017

Y Gao

5

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20 December 2017

Q K Hu

6

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20 December 2017

R P Feng

7

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20 December 2017

Y Z Liu

8

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20 December 2017

G C Ren

9

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20 December 2017

C Y Zhang

10

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20 December 2017

T P Hong

11

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20 December 2017

X Gao

12

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20 December 2017

L S Li

13

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20 December 2017

publication date

26 November 2008

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20 December 2017

published in

Diabetologia

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20 December 2017

volume

52

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20 December 2017

issue

3

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20 December 2017

page(s)

504-513

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20 December 2017

https://scigraph.springernature.com/pub.10.1007/s00125-008-1210-x

exact match

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cites work

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

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Crossref

https://api.crossref.org/works/10.1007%2FS00125-008-1210-X

Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells

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Standards of medical care in diabetes--2007.

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Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity

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Pax-6, a murine paired box gene, is expressed in the developing CNS

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12 December 2020

Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes

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12 December 2020

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

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12 December 2020

Insulin responsiveness of the glucagon gene conferred by interactions between proximal promoter and more distal enhancer-like elements involving the paired-domain transcription factor Pax6.

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12 December 2020

A new set of primers for mutation analysis of the human PAX6 gene

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12 December 2020

Hyperproinsulinemia of type II diabetes is not present before the development of hyperglycemia.

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12 December 2020

Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell

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12 December 2020

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells

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12 December 2020

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

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12 December 2020

PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans.

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12 December 2020

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

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12 December 2020

Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice

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12 December 2020

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

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12 December 2020

Effects of cyclosporin A on gene expression profiles of NIT-1 pancreatic beta cell line

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12 December 2020

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

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12 December 2020

PAX6, paired domain influences sequence recognition by the homeodomain

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12 December 2020

Overstimulation and beta-cell function

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12 December 2020

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

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12 December 2020

Pax genes and their roles in cell differentiation and development

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12 December 2020

PAX6 mutation as a genetic factor common to aniridia and glucose intolerance

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12 December 2020

Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription

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12 December 2020

Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters

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12 December 2020

Analysis of the gene encoding human PC2, a prohormone processing enzyme

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12 December 2020

Special Report: The 1996 Guide for the Care and Use of Laboratory Animals

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12 December 2020

Localization of the gene encoding peptidylglycine alpha-amidating monooxygenase (PAM) to human chromosome 5q14-5q21

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12 December 2020

A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto)

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12 December 2020

Processing of protein precursors by a novel family of subtilisin-related mammalian endoproteases

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12 December 2020

The incidence of PAX6 mutation in patients with simple aniridia: an evaluation of mutation detection in 12 cases.

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12 December 2020

Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8.

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12 December 2020

Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line

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12 December 2020

Adult pancreatic islets require differential pax6 gene dosage

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12 December 2020

Evolution and role of Pax genes

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12 December 2020

Isolation, culture, and characterization of endocrine cells from 6-month-old porcine pancreas

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12 December 2020

Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans

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12 December 2020

10.1007/S00125-008-1210-X

Identifiers

DOI

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20 December 2017

PubMed ID

19034419

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20 December 2017