(Q46264550)

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Trapping the monomer of a non-amyloidogenic variant of transthyretin: exploring its possible use as a therapeutic strategy against transthyretin amyloidogenic diseases.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Trapping the monomer of a non-amyloidogenic variant of transthyretin: exploring its possible use as a therapeutic strategy against transthyretin amyloidogenic diseases (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Fernando L. Palhano

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

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Larissa P Leme

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Roberta G Busnardo

3

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25 December 2019

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4 November 2008

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25 December 2019

Journal of Biological Chemistry

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

284

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

3

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25 December 2019

1443-1453

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Transthyretin: a review from a structural perspective.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Fibril in senile systemic amyloidosis is derived from normal transthyretin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Neurodegeneration in familial amyloid polyneuropathy: from pathology to molecular signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Comparative stability and clearance of [Met30]transthyretin and [Met119]transthyretin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Comparison of Lethal and Nonlethal Transthyretin Variants and Their Relationship to Amyloid Disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

The biological and chemical basis for tissue-selective amyloid disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Capture of a dimeric intermediate during transthyretin amyloid formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

The preaggregated state of an amyloidogenic protein: hydrostatic pressure converts native transthyretin into the amyloidogenic state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Intriguing nucleic-acid-binding features of mammalian prion protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Pressure-induced reversible dissociation of enolase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Trans-suppression of misfolding in an amyloid disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

The pathway by which the tetrameric protein transthyretin dissociates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

New insights into the mechanisms of protein misfolding and aggregation in amyloidogenic diseases derived from pressure studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

4,4'-Bis (1-anilinonaphthalene 8-sulfonate) (bis-ANS): a new probe of the active site of myosin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Negative cooperativity in the binding of thyroxine to human serum prealbumin. Preparation of tritium-labeled 8-anilino-1-naphthalenesulfonic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Revisiting volume changes in pressure-induced protein unfolding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Liver transplantation and new therapeutic approaches for familial amyloidotic polyneuropathy (FAP).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Rational design of potent human transthyretin amyloid disease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Tabulation of human transthyretin (TTR) variants, 2003

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807100200

21 January 2018

Identifiers

10.1074/JBC.M807100200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18984591%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

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