(Q46280203)

English

The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells

scientific article published in January 1993

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

0 references

author name string

A Sarkar

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

M E Dolan

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

G G Gonzalez

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

L J Marton

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

A E Pegg

5

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

D F Deen

6

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

publication date

1 January 1993

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

32

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

6

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

477-481

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

https://scigraph.springernature.com/pub.10.1007/bf00685893

0 references

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

1 reference

https://api.crossref.org/works/10.1007%2FBF00685893

21 January 2018

Chemosensitization of cultured human carcinoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by difluoromethylornithine-induced polyamine depletion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyamine metabolism and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea; NSC-409962) in the treatment of malignant brain tumor--a preliminary report

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxic cells as specific drug targets for chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic attack of hypoxic cells of solid tumors: presidential address

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of nitrosoureas to cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of human lymphocyte O6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and expression of the adaptive response to alkylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth state-dependent alterations in the ability of 12-O-tetradecanoylphorbol-13-acetate to increase ornithine decarboxylase activity in Reuber h35 Hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of mitomycin C for aerobic and hypoxic cells in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyamines in mammalian ageing: an oncological problem, too? A review

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for ornithine in the regulation of putrescine accumulation and ornithine decarboxylase activity in Reuber H35 hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biphasic induction of ornithine decarboxylase and putrescine levels in growing HTC cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of hypoxia on 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alpha-difluoromethylornithine on 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum(II) cytotoxicity, DNA interstrand cross-linking, and growth in human brain tumor cell lines in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the biochemistry of polyamines in eukaryotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of carcinogenesis induced by alkylating agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSaIIC murine fibrosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor hypoxia: its impact on cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8258197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00685893

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/8258197

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