(Q46285756)

English

Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder

scientific article published on 11 October 2017

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scholarly article

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder (English)

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

author name string

K R Vogel

1

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

G R Ainslie

2

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

A McConnell

3

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

J-B Roullet

4

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

K M Gibson

5

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

publication date

11 October 2017

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

Toxicology in Vitro

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

46

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

203-212

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

Examination of the superoxide/hydrogen peroxide forming and quenching potential of mouse liver mitochondria

1 reference

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In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding.

1 reference

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A pharmacokinetic evaluation and metabolite identification of the GHB receptor antagonist NCS-382 in mouse informs novel therapeutic strategies for the treatment of GHB intoxication

1 reference

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1 reference

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Mechanisms for the Specific Properties of γ-Hydroxybutyrate in Brain

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29 September 2018

Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and L-lactate in rats

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In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.

1 reference

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A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose

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Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.

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Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition

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GHB receptor targets in the CNS: focus on high-affinity binding sites

1 reference

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α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

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Development of the GABAergic system from birth to adolescence

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Why the need for qPCR publication guidelines?--The case for MIQE.

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Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells

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Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men

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gamma-Hydroxybutyrate binds to the synaptic site recognizing succinate monocarboxylate: a new hypothesis on astrocyte-neuron interaction via the protonation of succinate

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Gamma-hydroxybutyrate increases gastric emptying in rats.

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12 December 2020

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Identifiers

10.1016/J.TIV.2017.10.015

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

0 references

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/29031482

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