(Q46298902)

21 December 2017

title

Homoharringtonine inhibits the AKT pathway and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells (English)

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21 December 2017

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Haitao Meng

1

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21 December 2017

Chunmei Yang

2

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21 December 2017

Jie Jin

3

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21 December 2017

Yuhong Zhou

4

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21 December 2017

Wenbin Qian

5

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21 December 2017

publication date

1 October 2008

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21 December 2017

published in

Leukemia & Lymphoma

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21 December 2017

volume

49

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21 December 2017

issue

10

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21 December 2017

page(s)

1954-1962

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21 December 2017

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

cites work

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells is mediated by the endoplasmic reticulum stress pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Phase II study of low-dose continuous infusion homoharringtonine in refractory acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Homoharringtonine induces apoptosis and growth arrest in human myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Advances in biology of multiple myeloma: clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

The AKT kinase is activated in multiple myeloma tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10428190802320368

10.1080/10428190802320368

21 January 2018

Identifiers

DOI

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21 December 2017

1 reference

21 December 2017