(Q46326663)

English

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists

scientific article published in November 2008

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

1 reference

based on heuristic

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W Tang

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

R A Stearns

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

R W Wang

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

R R Miller

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

Q Chen

5

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

J Ngui

6

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

R K Bakshi

7

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

R P Nargund

8

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

D C Dean

9

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

T A Baillie

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

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publication date

1 November 2008

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

38

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

11

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

1437-1451

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Quinone-sensitized steady-state photolysis of acetophenone oximes under aerobic conditions: kinetics and product studies

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Kinetics of suicide substrates. Practical procedures for determining parameters

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites

1 reference

https://api.crossref.org/works/10.1080%2F00498250802464685

21 January 2018

Identifiers

10.1080/00498250802464685

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18841517

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