(Q46375972)

English

The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions? (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

Herbert Y. Meltzer

4

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5

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author name string

Marilyn A Davies

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

Beth Ann Compton-Toth

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

Sandra J Hufeisen

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

publication date

13 October 2004

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

number of pages

10

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based on heuristic

inferred from page(s)

Psychopharmacology

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

178

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

451-460

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

https://scigraph.springernature.com/pub.10.1007/s00213-004-2017-1

0 references

Muscarinic m4 receptor activation by some atypical antipsychotic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic hyperactivity and negative schizophrenic symptoms. A model of cholinergic/dopaminergic interactions in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G-protein-coupled receptors at a glance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variety of effects of trihexyphenidyl (THP) on schizophrenic and non-schizophrenic abusers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NNC 01-0687, a selective dopamine D1 receptor antagonist, in the treatment of schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes for schizophrenia? Recent findings and their pathophysiological implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M-100907 (Aventis).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of muscarinic m1 receptor genetic polymorphisms with psychiatric symptoms and cognitive function in schizophrenic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Typical and atypical antipsychotic occupancy of D2 and S2 receptors: an autoradiographic analysis in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarinic receptors in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BMY 14802, a sigma receptor ligand for the treatment of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the D3 and autoreceptor-preferring dopamine antagonist (+)-UH232 in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seroquel (ICI 204 636), a putative "atypical" antipsychotic, in schizophrenia with positive symptomatology: results of an open clinical trial and changes of neuroendocrinological and EEG parameters

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zacopride in schizophrenia: a single-blind serotonin type 3 antagonist trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antischizophrenic drugs and brain cholinergic receptors. Affinity for muscarinic sites predicts extrapyramidal effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Newer atypical antipsychotic medication in comparison to clozapine: a systematic review of randomized trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of the conditioned response and the counteraction of schizophrenia by muscarinic stimulation of the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo determination of muscarinic acetylcholine receptor availability in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic aspects of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of efficacy of the 5-HT3 receptor antagonist granisetron in the treatment of acute neuroleptic-induced akathisia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioreceptor binding profile of the atypical antipsychotic olanzapine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine is a potent and selective muscarinic M4 receptor agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haloperidol and clozapine treatment and their effect on M-chlorophenylpiperazine-mediated responses in schizophrenia: implications for the mechanism of action of clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SB-277011 GlaxoSmithKline.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central muscarinic acetylcholine receptor availability in patients treated with clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane .

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarinic receptors as a target for drugs treating schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences between natural and recombinant G protein-coupled receptor systems with varying receptor/G protein stoichiometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homologous and heterologous phosphorylation of the vasopressin V1a receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15765260

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-004-2017-1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15765260

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