(Q46397532)

English

Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice

scientific article published on 2 September 2008

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scholarly article

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice (English)

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

glucose intolerance

1 reference

based on heuristic

inferred from title

author name string

Akiko Matsuyama-Yokono

1

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

Atsuo Tahara

2

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

Ryosuke Nakano

3

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

Yuka Someya

4

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

Masahiko Hayakawa

5

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

Masayuki Shibasaki

6

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

language of work or name

1 reference

based on heuristic

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publication date

2 September 2008

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

Naunyn-Schmiedeberg's Archives of Pharmacology

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

379

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

2

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

191-199

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

https://scigraph.springernature.com/pub.10.1007/s00210-008-0348-x

0 references

Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0348-X

21 January 2018

Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary whey protein modulates liver glycogen level and glycoregulatory enzyme activities in exercise-trained rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of gut hormones in glucose homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of efficacy, secondary failure rate, and complications of sulfonylureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin secretory response in Japanese type 2 (non-insulin-dependent) diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postprandial blood glucose. American Diabetes Association

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incretins and the development of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glibenclamide-associated hypoglycaemia: a report on 57 cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Standards of medical care in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Banting lecture 1990. Beta-cells in type II diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Higher incidence of severe hypoglycaemia leading to hospital admission in Type 2 diabetic patients treated with long-acting versus short-acting sulphonylureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of Exogenous or Endogenous Gastric Inhibitory Polypeptide (GIP) on Plasma Triglyceride Responses in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/18762913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-008-0348-X

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18762913

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