(Q46404885)

21 December 2017

title

The uptake of 3'-deoxy-3'-[18F]fluorothymidine into L5178Y tumours in vivo is dependent on thymidine kinase 1 protein levels (English)

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21 December 2017

author name string

Henryk Barthel

1

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21 December 2017

Meg Perumal

2

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21 December 2017

John Latigo

3

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21 December 2017

Qimin He

4

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21 December 2017

Frank Brady

5

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21 December 2017

Sajinder K Luthra

6

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21 December 2017

Pat M Price

7

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21 December 2017

Eric O Aboagye

8

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21 December 2017

publication date

4 September 2004

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21 December 2017

European Journal of Nuclear Medicine and Molecular Imaging

published in

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21 December 2017

volume

32

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21 December 2017

issue

3

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21 December 2017

page(s)

257-263

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21 December 2017

https://scigraph.springernature.com/pub.10.1007/s00259-004-1611-0

exact match

0 references

cites work

Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents

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https://api.crossref.org/works/10.1007%2FS00259-004-1611-0

Sequence analysis of tka(-)-1 and tkb(+)-1 alleles in L5178Y tk+/- mouse-lymphoma cells and spontaneous tk-/- mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00259-004-1611-0

Thymidine kinase activity and trifluorothymidine resistance of spontaneous and mutagen-induced L5178Y cells in RPMI 1640 medium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00259-004-1611-0

Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00259-004-1611-0

3-deoxy-3-[(18)F]fluorothymidine-positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules.

21 January 2018

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12 December 2020

Human thymidine kinase 1. Regulation in normal and malignant cells

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12 December 2020

Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test

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12 December 2020

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography

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12 December 2020

Monitoring tumor cell proliferation by targeting DNA synthetic processes with thymidine and thymidine analogs.

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12 December 2020

The HIV replication inhibitor 3'-fluoro-3'-deoxythymidine blocks sialylation of N-linked oligosaccharides

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12 December 2020

Pharmacokinetic/pharmacodynamic study of ZD9331, a nonpolyglutamatable inhibitor of thymidylate synthase, in a murine model following two curative administration schedules

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12 December 2020

Thymidine kinase isoenzymes in human malignant lymphoma

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12 December 2020

Mutant frequencies and loss of heterozygosity induced by N-ethyl-N-nitrosourea in the thymidine kinase gene of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells

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12 December 2020

Basis of FLT as a cell proliferation marker: comparative uptake studies with [3H]thymidine and [3H]arabinothymidine, and cell-analysis in 22 asynchronously growing tumor cell lines

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12 December 2020

Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG.

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12 December 2020

Detection and grading of soft tissue sarcomas of the extremities with (18)F-3'-fluoro-3'-deoxy-L-thymidine.

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12 December 2020

In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography

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12 December 2020

Constitutive protection of E2F recognition sequences in the human thymidine kinase promoter during cell cycle progression.

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12 December 2020

Mutagenicity of 2-amino-N6-hydroxyadenine (AHA) at three loci in L5178Y/tk± mouse lymphoma cells: molecular and preliminary cytogenetic characterizations of AHA-induced tk−/− mutants

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12 December 2020

3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography.

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12 December 2020

[18F]FLT PET for diagnosis and staging of thoracic tumours

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12 December 2020

The use of L5178Y mouse lymphoma cells to assess the mutagenic, clastogenic and aneugenic properties of chemicals.

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12 December 2020

Pharmacodynamics of radiolabelled anticancer drugs for positron emission tomography

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12 December 2020

Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.

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12 December 2020

Differential phosphorylation of human thymidine kinase in proliferating and M phase-arrested human cells

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12 December 2020

Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography

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12 December 2020

How much gets there and what does it do?: The need for better pharmacokinetic and pharmacodynamic endpoints in contemporary drug discovery and development

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12 December 2020

Regulation of human thymidine kinase during the cell cycle

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12 December 2020

Overexpression of human thymidine kinase mRNA without corresponding enzymatic activity in patients with chronic lymphatic leukemia

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12 December 2020

Cell-cycle targeted therapies

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12 December 2020

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

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12 December 2020

In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumor

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12 December 2020

Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.

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12 December 2020

Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.

1 reference

12 December 2020

10.1007/S00259-004-1611-0

Identifiers

DOI

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21 December 2017

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21 December 2017