(Q46423291)

22 December 2017

title

Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation (English)

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22 December 2017

author name string

Zhi-Ying Chen

1

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22 December 2017

Efren Riu

2

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22 December 2017

Chen-Yi He

3

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22 December 2017

Hui Xu

4

1 reference

22 December 2017

Mark A Kay

5

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22 December 2017

publication date

5 February 2008

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22 December 2017

published in

Molecular Therapy

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22 December 2017

volume

16

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22 December 2017

issue

3

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22 December 2017

page(s)

548-556

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22 December 2017

Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Complete and sustained phenotypic correction of hemophilia B in mice following hepatic gene transfer of a high-expressing human factor IX plasmid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

In vitro and in vivo comparative study of chimeric liver-specific promoters

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Reducing the immunostimulatory activity of CpG-containing plasmid DNA vectors for non-viral gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Toxicity of cationic lipid-DNA complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

A Toll-like receptor recognizes bacterial DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Reading the DNA methylation signal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

The Ski protein family is required for MeCP2-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Dynamic DNA methylation and histone modifications contribute to lentiviral transgene silencing in murine embryonic carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Heterochromatin and epigenetic control of gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

HP1 and the dynamics of heterochromatin maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Gene activation and deactivation related changes in the three-dimensional structure of chromatin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

RNA polymerase II elongation through chromatin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300399

1 reference

22 December 2017

PubMed ID

18253155

1 reference

22 December 2017