(Q46486255)

22 December 2017

title

GABA signalling: therapeutic targets for epilepsy, Parkinson's disease and Huntington's disease (English)

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22 December 2017

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Kleppner SR

1

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22 December 2017

Tobin AJ

series ordinal

2

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22 December 2017

language of work or name

English

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publication date

1 April 2001

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22 December 2017

Expert Opinion on Therapeutic Targets

published in

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22 December 2017

volume

5

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22 December 2017

issue

2

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22 December 2017

page(s)

219-239

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22 December 2017

Two genes encode distinct glutamate decarboxylases

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GABAA receptor channels

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The GABA-A receptor gene family: new targets for therapeutic intervention

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Heterodimerization is required for the formation of a functional GABA(B) receptor

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GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

21 January 2018

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21 January 2018

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Transient increase in expression of a glutamate decarboxylase (GAD) mRNA during the postnatal development of the rat striatum

21 January 2018

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Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway

21 January 2018

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Different distributions of GAD65 and GAD67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles.

21 January 2018

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21 January 2018

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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

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Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

21 January 2018

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Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.

21 January 2018

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Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

21 January 2018

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Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

21 January 2018

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21 January 2018

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Central benzodiazepine receptor autoradiography in hippocampal sclerosis

21 January 2018

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GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy.

21 January 2018

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21 January 2018

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21 January 2018

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GABA-mediated synchronous potentials and seizure generation

21 January 2018

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21 January 2018

GABA and epileptogenesis

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Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

21 January 2018

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Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA

21 January 2018

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Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures

21 January 2018

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Head orientation and trajectory of locomotion during jumping and walking in domestic chicks.

21 January 2018

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Conditionally-immortalized astrocytic cell line expresses GAD and secretes GABA under tetracycline regulation

21 January 2018

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Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra.

21 January 2018

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Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Consequences of nigrostriatal denervation on the gamma-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes

21 January 2018

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Glutamate decarboxylase (GAD67 and GAD65) gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian monkeys.

21 January 2018

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6-Hydroxydopamine lesions of the nigrostriatal pathway alter the expression of glutamate decarboxylase messenger RNA in rat globus pallidus projection neurons

21 January 2018

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A post mortem study on neurochemical markers of dopaminergic, GABA-ergic and glutamatergic neurons in basal ganglia-thalamocortical circuits in Parkinson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.2.219

Elevated gamma-aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson's disease: correlation with striatal dopamine loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.2.219

Differential regulation of glutamate, aspartate and gamma-amino-butyrate release by N-methyl-D-aspartate receptors in rat striatum after partial and extensive lesions to the nigro-striatal dopamine pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.2.219

Further investigations into the pathophysiology of MPTP-induced parkinsonism in the primate: an intracerebral microdialysis study of gamma-aminobutyric acid in the lateral segment of the globus pallidus

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.2.219

GABAA receptor complex function in frontal cortex membranes from control and neurological patients

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.2.219

Changes in benzodiazepine and acetylcholine receptors in the globus pallidus in Parkinson's disease

21 January 2018

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Regional and cellular localisation of GABA(A) receptor subunits in the human basal ganglia: An autoradiographic and immunohistochemical study.

21 January 2018

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Stereotactic pallidotomy in the treatment of Parkinson disease: an expert opinion

21 January 2018

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Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases

21 January 2018

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Fetal nigral transplantation as a therapy for Parkinson's disease

21 January 2018

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Cerebral implantation in movement disorders: state of the art.

21 January 2018

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Striatal and nigral neuron subpopulations in rigid Huntington's disease: implications for the functional anatomy of chorea and rigidity-akinesia

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.2.219

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

21 January 2018

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Preproenkephalin messenger RNA?containing neurons in striatum of patients with symptomatic and presymptomatic huntington's disease: An in situ hybridization study

21 January 2018

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Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

21 January 2018

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Reduction in enkephalin and substance P messenger RNA in the striatum of early grade Huntington's disease: a detailed cellular in situ hybridization study

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.2.219

Differential loss of striatal projection neurons in Huntington disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.2.219

Chemical and anatomical changes in the striatum and substantia nigra following quinolinic acid lesions in the striatum of the rat: a detailed time course of the cellular and GABA(A) receptor changes.

21 January 2018

1 reference

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Motor and cognitive improvements in patients with Huntington's disease after neural transplantation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.5.2.219

Hippocampal GABA transporter function in temporal-lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.5.2.219

21 January 2018

Identifiers

DOI

10.1517/14728222.5.2.219

1 reference

22 December 2017

1 reference

22 December 2017