(Q46498636)

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Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus.

scientific article published on 10 January 2014

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7 March 2020

Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus (English)

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7 March 2020

multiple drug resistance

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Rosalinde Masereeuw

6

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7 March 2020

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7 March 2020

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Azza A K El-Sheikh

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7 March 2020

Jan B Koenderink

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7 March 2020

Alfons C Wouterse

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7 March 2020

Petra H H van den Broek

4

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7 March 2020

Vivienne G M Verweij

5

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7 March 2020

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10 January 2014

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7 March 2020

Translational Research

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7 March 2020

164

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7 March 2020

1

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7 March 2020

46-56

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7 March 2020

Reviewing the evidence for de novo immunosuppression with sirolimus

1 reference

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Use of mycophenolic acid in non-transplant renal diseases

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Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes

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Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability

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Therapeutic drug measurement of mycophenolic acid derivatives in transplant patients.

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Pharmacokinetic role of protein binding of mycophenolic acid and its glucuronide metabolite in renal transplant recipients

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Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients

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7 January 2021

Effect of cyclosporine on mycophenolic acid area under the concentration-time curve in pediatric kidney transplant recipients

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7 January 2021

Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid

1 reference

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7 January 2021

Influence of cyclosporine on the serum concentration and biliary excretion of mycophenolic acid and 7-O-mycophenolic acid glucuronide

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7 January 2021

Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

1 reference

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7 January 2021

Role of Mrp2 in the hepatic disposition of mycophenolic acid and its glucuronide metabolites: effect of cyclosporine

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7 January 2021

Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

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7 January 2021

Mechanisms of renal anionic drug transport

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7 January 2021

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

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7 January 2021

Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus

1 reference

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Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats.

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Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.

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Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.

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7 January 2021

Uncertainty factors for chemical risk assessment: interspecies differences in glucuronidation

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7 January 2021

Influence of uridine diphosphate (UDP)-glucuronosyltransferases and ABCC2 genetic polymorphisms on the pharmacokinetics of mycophenolic acid and its metabolites in Chinese renal transplant recipients

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7 January 2021

UGT1A9 -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients

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7 January 2021

UGT1A9, UGT2B7, and MRP2 genotypes can predict mycophenolic acid pharmacokinetic variability in pediatric kidney transplant recipients

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7 January 2021

Severe toxicity associated with a markedly elevated mycophenolic acid free fraction in a renal transplant recipient

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7 January 2021

The impact of P-glycoprotein and Mrp2 on mycophenolic acid levels in mice

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7 January 2021

Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients

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7 January 2021

SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients

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7 January 2021

Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters

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Expression of ATP-binding cassette membrane transporters in rodent and human sertoli cells: relevance to the permeability of antiretroviral therapy at the blood-testis barrier

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Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human

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Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.

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Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human.

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Species differences in UDP-glucuronosyltransferase activities in mice and rats.

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Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl]rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro

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