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AP2 associated kinase 1
mammalian protein found in Homo sapiens
AAK1
AP2-associated protein kinase 1
adaptor-associated kinase 1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2M2I8
part of
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q2M2I8
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serine/threonine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2M2I8
encoded by
AAK1
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2M2I8
molecular function
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
AP-2 adaptor complex binding
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
nucleotide binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
protein kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
Notch binding
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IPI
ATP binding
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
protein serine/threonine kinase activity
determination method
IBA
IEA
ISS
TAS
4 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IBA
cell component
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
plasma membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
terminal bouton
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
ISS
cell leading edge
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
ISS
clathrin-coated pit
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
extrinsic component of plasma membrane
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
ISS
clathrin-coated vesicle
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
ISS
cytoplasm
determination method
IBA
1 reference
retrieved
27 March 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q2M2I8&geneProductId=UniProtKB:Q2M2I8
determination method
IBA
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
TAS
nucleus
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IBA
biological process
endocytosis
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
phosphorylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
protein stabilization
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
regulation of protein localization
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
protein autophosphorylation
determination method
ISS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
ISS
positive regulation of Notch signaling pathway
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
protein phosphorylation
determination method
IEA
IDA
3 references
retrieved
27 March 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q2M2I8&geneProductId=UniProtKB:Q2M2I8
determination method
IEA
retrieved
27 March 2018
stated in
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q2M2I8&geneProductId=UniProtKB:Q2M2I8
determination method
IDA
retrieved
27 March 2018
stated in
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q2M2I8&geneProductId=UniProtKB:Q2M2I8
determination method
IDA
regulation of clathrin-dependent endocytosis
determination method
IMP
IDA
2 references
retrieved
8 April 2019
stated in
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IMP
retrieved
8 April 2019
stated in
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
membrane organization
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
TAS
protein phosphorylation
determination method
IBA
IDA
IEA
4 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IEA
retrieved
8 April 2019
stated in
AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
retrieved
8 April 2019
stated in
A novel AAK1 splice variant functions at multiple steps of the endocytic pathway
GOA
curator
UniProt
UniProt protein ID
Q2M2I8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q2M2I8
determination method
IBA
regulation of endocytosis
determination method
IBA
1 reference
retrieved
10 September 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q2M2I8&geneProductId=UniProtKB:Q2M2I8
determination method
IBA
EC enzyme number
2.7.11.1
0 references
Gene Atlas image
PBB GE AAK1 205435 s at fs.png
732 × 530; 12 KB
0 references
has part(s)
serine/threonine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q2M2I8
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q2M2I8
Identifiers
RefSeq protein ID
NP_055726
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
22848
NP_001358504
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
22848
NP_001358506
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
22848
UniProt protein ID
Q2M2I8
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q2M2I8
Ensembl protein ID
ENSP00000385181
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000385181
ENSP00000386456
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000386456
ENSP00000386342
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000386342
ENSP00000485296
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000485296
ENSP00000485350
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000485350
ENSP00000485409
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000485409
PDB structure ID
4WSQ
1 reference
stated in
UniProt
UniProt protein ID
Q2M2I8
retrieved
30 June 2016
language of work or name
English
5L4Q
1 reference
stated in
UniProt
UniProt protein ID
Q2M2I8
retrieved
30 June 2016
language of work or name
English
Sitelinks
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Wikiquote
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Wikisource
(0 entries)
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Wikiversity
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Multilingual sites
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