(Q46504849)

22 December 2017

title

Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers (English)

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22 December 2017

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5

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22 December 2017

author name string

Eric Lévesque

1

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22 December 2017

Marie-Odile Benoit-Biancamano

2

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22 December 2017

Robert Delage

3

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22 December 2017

Félix Couture

4

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22 December 2017

publication date

1 July 2008

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22 December 2017

published in

Pharmacogenomics

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22 December 2017

volume

9

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22 December 2017

issue

7

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22 December 2017

page(s)

869-879

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22 December 2017

Mycophenolates in transplantation

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The kinetics of mycophenolic acid and its glucuronide metabolite in adult kidney transplant recipients

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Highly variable mycophenolate mofetil bioavailability following nonmyeloablative hematopoietic cell transplantation.

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Relationship of mycophenolic acid exposure to clinical outcome after hematopoietic cell transplantation

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The impact of routine mycophenolate mofetil drug monitoring on the treatment of cardiac allograft rejection

21 January 2018

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Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration

21 January 2018

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Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

21 January 2018

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The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

21 January 2018

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Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

21 January 2018

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Role of Mrp2 in the hepatic disposition of mycophenolic acid and its glucuronide metabolites: effect of cyclosporine

21 January 2018

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Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes

21 January 2018

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The acyl glucuronide metabolite of mycophenolic acid inhibits the proliferation of human mononuclear leukocytes

21 January 2018

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A new acute inflammatory syndrome related to the introduction of mycophenolate mofetil in patients with Wegener's granulomatosis

21 January 2018

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Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid

21 January 2018

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A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

21 January 2018

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The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

21 January 2018

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Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

21 January 2018

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21 January 2018

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Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats.

21 January 2018

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Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.

21 January 2018

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Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

21 January 2018

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A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination

21 January 2018

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A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

21 January 2018

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https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Clinical pharmacokinetics of mycophenolate mofetil

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients.

21 January 2018

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UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

21 January 2018

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The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

21 January 2018

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Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.7.869

21 January 2018

Identifiers

DOI

10.2217/14622416.9.7.869

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22 December 2017

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22 December 2017